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  • Synthesis and biological activity of modified thiopyrimidine nucleosides.

Synthesis and biological activity of modified thiopyrimidine nucleosides.

Nucleosides & nucleotides (2000-01-05)
A M Attia, M A Sallam, A A Almehdi, M M Abbasi
ABSTRACT

N3-beta-D-glucopyranosyl, galactopyranosyl and xylopyranosyl 6-methyl-2-methylthiouracil and their 5-bromo derivatives have been synthesized by coupling an alpha-acetobromosugar with the corresponding thiouracil. The new modified thiouridine analogues were evaluated for their inhibitory activity against Human Immunodeficiency Virus (HIV) replication in MT-4 cells as well as for their cytotoxicity.

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6-Methyl-2-thiouracil, purum, ≥98.0% S basis (elemental analysis)
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Supelco
6-Methyl-2-thiouracil, VETRANAL®, analytical standard
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