- Inhibition of matrix metalloproteinase-1 by dichloromethylene bisphosphonate (clodronate).
Inhibition of matrix metalloproteinase-1 by dichloromethylene bisphosphonate (clodronate).
Calcified tissue international (1997-07-01)
O Teronen, Y T Konttinen, C Lindqvist, T Salo, T Ingman, A Lauhio, Y Ding, S Santavirta, H Valleala, T Sorsa
PMID9192515
ABSTRACT
Interstitial collagenase present in human jaw cyst extract and purified human fibroblast-type collagenase (MMP-1) were both efficiently inhibited in vitro by clodronate, an osteoactive, antiresorptive bisphosphonate. The IC50 of clodronate to inhibit MMP-1 is 150 microM. These findings suggest an extended and hitherto undescribed properties for clodronate/biphosphonates in prevention and treatment of tissue degradation in both bone and soft tissue destructive diseases.
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