SML1567
MCB-613
≥98% (HPLC)
Synonym(s):
4-Ethyl-2,6-bis(pyridin-3-ylmethylene)cyclohexanone
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About This Item
Empirical Formula (Hill Notation):
C20H20N2O
CAS Number:
Molecular Weight:
304.39
UNSPSC Code:
51111800
NACRES:
NA.77
Recommended Products
Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 5 mg/mL, clear (warmed)
storage temp.
2-8°C
General description
MCB-613 (4-Ethyl-2,6-bis-pyridin-3-ylmethylene-cyclohexanone) belongs to the chalcone class of compounds. It is an anti-neoplastic compound.
Application
MCB-613 has been used to study the molecular mechanism of MCB-613-induced cell death.
Biochem/physiol Actions
MCB-613 is a pan-Steroid Receptor Coactivator (SRC) stimulator. There are three steroid receptor coactivators (SRC) that interact with transcription factors and whose overexpression is assciated with a number of cancers, particularly breast cancer. MCB-613 overstimulates SRC activity in cancer cells resulting in excessive generation of reactive oxygen species (ROS), leading to cell stress and death by a process called paraptosis. MCB-613 is a cytotoxic molecule which can kill various human cancer cell lines, like HepG2 (liver), PC-3 (prostate) and MCF-7 (breast) cells.
MCB-613 is capable of inducing the transcriptional activity of steroid receptor coactivators (SRCs).
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Hyperactivation of nuclear receptor coactivators induces PERK-dependent cell death
Hossain MM, et al.
Testing, 9(14), 11707-11707 (2018)
Lei Wang et al.
Cancer cell, 28(2), 240-252 (2015-08-13)
By integrating growth pathways on which cancer cells rely, steroid receptor coactivators (SRC-1, SRC-2, and SRC-3) represent emerging targets in cancer therapeutics. High-throughput screening for SRC small molecule inhibitors (SMIs) uncovered MCB-613 as a potent SRC small molecule "stimulator" (SMS).
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