A5638

Adenosine 2′,5′-diphosphate sodium salt

≥95%

• Synonym(s): 2′-Phosphoadenosine 5′-phosphate sodium salt
• Empirical Formula (Hill Notation): C₁₀H₁₅N₅O₁₀P₂ · xNa⁺
• CAS Number: 154146-84-6
• Molecular Weight: 427.20 (free acid basis)
• UNSPSC Code: 41106305
• PubChem Substance ID: 24891005
• NACRES: NA.51

Properties

• Assay: ≥95%
• form: powder
• solubility: water: 50 mg/mL, clear, colorless to faintly yellow
• storage temp.: −20°C
• SMILES string: Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3OP(O)(O)=O
• InChI: 1S/C10H15N5O10P2.Na/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(25-27(20,21)22)6(16)4(24-10)1-23-26(17,18)19;/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22);
• InChI key: OHPUPSOOFQPMRP-UHFFFAOYSA-N

Description

Application

Adenosine 2′,5′-diphosphate may be used to study the mechanisms and activities of these components. Adenosine 2′,5′-diphosphate may be used to prepare adenosine 2′,5′-diphosphate agarose for affinity chromatography purification of enzymes such as NADPH-cytochrome P450 reductase and glutathione reductase.

Biochem/physiol Actions

Adenosine 2′,5′-diphosphate (A2P5P) is a competitive antagonist of the P2Y1 receptor and a non-selective antagonist of the platelet P2X1 ion channel. A2P5P prevents ADP-induced platelet aggregation and deformation but it does not affect ADP-induced inhibition of adenylyl cyclase.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves