Manganese neurotoxicity and the role of reactive oxygen species.

Manganese neurotoxicity and the role of reactive oxygen species.

Free radical biology & medicine (2013-02-12)

Ebany J Martinez-Finley, Claire E Gavin, Michael Aschner, Thomas E Gunter

摘要

Manganese (Mn) is an essential dietary nutrient, but an excess or accumulation can be toxic. Disease states, such as manganism, are associated with overexposure or accumulation of Mn and are due to the production of reactive oxygen species, free radicals, and toxic metabolites; alteration of mitochondrial function and ATP production; and depletion of cellular antioxidant defense mechanisms. This review focuses on all of the preceding mechanisms and the scientific studies that support them as well as providing an overview of the absorption, distribution, and excretion of Mn and the stability and transport of Mn compounds in the body.

材料

货号

品牌

产品描述

463728

Sigma-Aldrich

锰, powder, ≥99.9% trace metals basis

266132

Sigma-Aldrich

锰, powder, −325 mesh, ≥99% trace metals basis

266167

Sigma-Aldrich

锰, chips, thickness <2.0 mm, 99%

GF83932768

锰, foil, 25x25mm, thickness 2mm, hot-pressed, 99.95%

GF94645233

锰, foil, not light tested, 50x50mm, thickness 0.025mm, permanent polyester support, 98.7%

GF11021094

锰, rod, 10mm, diameter 4.0mm, cast, 99.5%

GF42039918

锰, rod, 50mm, diameter 6.35mm, cast, 99.5%

GF87355334

锰, foil, 50x50mm, thickness 2mm, hot-pressed, 99.95%

GF38495885

锰, rod, 50mm, diameter 4.0mm, cast, 99.5%

GF81243929

锰, foil, not light tested, 25x25mm, thickness 0.001mm, permanent polyester support, 98.7%

GF05008092

锰, foil, not light tested, 25x25mm, thickness 0.005mm, permanent polyester support, 98.7%

GF24430395

锰, foil, not light tested, 25x25mm, thickness 0.025mm, permanent polyester support, 98.7%

GF00832081

锰, foil, not light tested, 50x50mm, thickness 0.015mm, permanent polyester support, 98.7%

GF58094635

锰, foil, not light tested, 25x25mm, thickness 0.004mm, permanent polyester support, 98.7%

GF70110593

锰, foil, not light tested, 25x25mm, thickness 0.006mm, permanent polyester support, 98.7%

GF94007594

锰, foil, not light tested, 25x25mm, thickness 0.003mm, permanent polyester support, 98.7%

GF90559794

锰, foil, not light tested, 25x25mm, thickness 0.02mm, permanent polyester support, 98.7%

GF03428625

锰, foil, not light tested, 25x25mm, thickness 0.05mm, permanent polyester support, 98.7%

GF92898983

锰, foil, not light tested, 25x25mm, thickness 0.009mm, permanent polyester support, 98.7%

GF94542206

锰, foil, not light tested, 25x25mm, thickness 0.0125mm, permanent polyester support, 98.7%

GF74177736

锰, foil, not light tested, 25x25mm, thickness 0.01mm, permanent polyester support, 98.7%

GF99005193

锰, foil, not light tested, 25x25mm, thickness 0.015mm, permanent polyester support, 98.7%

GF28884549

锰, foil, not light tested, 25x25mm, thickness 0.0025mm, permanent polyester support, 98.7%

GF86610539

锰, foil, not light tested, 50x50mm, thickness 0.0125mm, permanent polyester support, 98.7%

GF61911288

锰, foil, not light tested, 50x50mm, thickness 0.01mm, permanent polyester support, 98.7%

GF05710430

锰, foil, not light tested, 50x50mm, thickness 0.02mm, permanent polyester support, 98.7%

GF27632055

锰, foil, not light tested, 50x50mm, thickness 0.05mm, permanent polyester support, 98.7%

GF64815239

锰, foil, not light tested, 50x50mm, thickness 0.002mm, permanent polyester support, 98.7%

GF53469142

锰, foil, not light tested, 25x25mm, thickness 0.008mm, permanent polyester support, 98.7%

GF31519975

锰, foil, not light tested, 50x50mm, thickness 0.001mm, permanent polyester support, 98.7%