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Merck
  • Transition-metal-free synthesis of oxindoles by potassium tert-butoxide-promoted intramolecular α-arylation.

Transition-metal-free synthesis of oxindoles by potassium tert-butoxide-promoted intramolecular α-arylation.

Organic letters (2012-07-17)
Astrid Beyer, Julien Buendia, Carsten Bolm
摘要

Potassium tert-butoxide-mediated intramolecular α-arylations of fluoro- and chloro-substituted anilides provide oxindoles in DMF at 80 °C. In this manner, diversely substituted products have been obtained in moderate to high yields.

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Sigma-Aldrich
叔丁醇钾, reagent grade, ≥98%
Sigma-Aldrich
叔丁醇钾 溶液, 1.0 M in THF
Sigma-Aldrich
叔丁醇钾, sublimed grade, 99.99% trace metals basis