推荐产品
生物源
mouse
共軛
unconjugated
抗體表格
purified immunoglobulin
抗體產品種類
primary antibodies
無性繁殖
4B7, monoclonal
形狀
buffered aqueous solution
物種活性
human
技術
immunofluorescence: suitable
immunoprecipitation (IP): suitable
indirect ELISA: suitable
western blot: 1-5 μg/mL
同型
IgG2bκ
GenBank登錄號
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
基因資訊
human ... NEUROG3(50674)
一般說明
Neurogenin 3 (NEUROG3) is also termed as Ngn3. This protein belongs to the subfamily of basic-helix-loop-helix (bHLH) transcription factors. It is located on human chromosome 10q.
Neurogenin-3 (NEUROG3) is expressed in endocrine progenitor cells and is required for endocrine cell development in the pancreas and intestine (Wang et al., 2006 [PubMed 16855267]). It belongs to a family of basic helix-loop-helix transcription factors involved in the determination of neural precursor cells in the neuroectoderm (Gradwohl et al., 2000 [PubMed 10677506]).[supplied by OMIM]
免疫原
NEUROG3 (NP_066279, 1 a.a. ~ 101 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MTPQPSGAPTVQVTRETERSFPRASEDEVTCPTSAPPSPTRTRGNCAEAEEGGCRGAPRKLRARRGGRSRPKSELALSKQRRSRRKKANDRERNRMHNLN*
Sequence
MTPQPSGAPTVQVTRETERSFPRASEDEVTCPTSAPPSPTRTRGNCAEAEEGGCRGAPRKLRARRGGRSRPKSELALSKQRRSRRKKANDRERNRMHNLN*
生化／生理作用
Neurogenin 3 (NEUROG3) is required for all intestinal enteroendocrine cells. It participates in the differentiation of endocrine pancreas. This protein is also essential to induce islet cell maturation and to maintain islet function.
外觀
Solution in phosphate buffered saline, pH 7.4
法律資訊
GenBank is a registered trademark of United States Department of Health and Human Services
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
nwg
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium
Gerbe F, et al.
The Journal of Cell Biology, 192(5), 767-780 (2011)
Sustained Neurog3 expression in hormone-expressing islet cells is required for endocrine maturation and function
Wang S, et al.
Proceedings of the National Academy of Sciences of the USA, 106(24), 9715-9720 (2009)
Abel L Carcagno et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(46), 15223-15233 (2014-11-14)
The development of the nervous system is critically dependent on the production of functionally diverse neuronal cell types at their correct locations. In the embryonic neural tube, dorsoventral signaling has emerged as a fundamental mechanism for generating neuronal diversity. In
Polymorphisms in the neurogenin 3 gene (NEUROG) and their relation to altered insulin secretion and diabetes in the Danish Caucasian population
Jensen JN, et al.
Diabetologia, 44(1), 123-126 (2001)
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