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品質等級
化驗
≥98% (HPLC)
形狀
powder
顏色
white to beige
溶解度
DMSO: 2 mg/mL, clear
儲存溫度
2-8°C
SMILES 字串
O=C1C2=C(C(C1C3=CC=C(C=C3)F)=O)C=CC=C2
InChI
1S/C15H9FO2/c16-10-7-5-9(6-8-10)13-14(17)11-3-1-2-4-12(11)15(13)18/h1-8,13H
InChI 密鑰
NASXCEITKQITLD-UHFFFAOYSA-N
生化／生理作用
Fluindione is an orally active vitamin K antagonist (VKA) that exerts its in vivo anticoagulant efficacy by inhibiting the vitamin K epoxide reductase activity (VKOR IC50 = 6.6 nM) in a substrate-comeptitive manner.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Role of ABC transporters in trans-epithelial transport of vitamin K antagonists
Bernadette Espana , Caroline Prouillac
Biopharmaceutics & Drug Disposition, 38, 20-32 (2017)
Antithrombotic efficacy of the vitamin K antagonist fluindione in a human Ex vivo model of arterial thrombosis : effect of anticoagulation level and combination therapy with aspirin
Bossavy JP, Sakariassen KS, Thalamas C, Boneu B, Cadroy Y
Arteriosclerosis, Thrombosis, and Vascular Biology, 19, 2269-2275 (1999)
Jonaz Font et al.
Fundamental & clinical pharmacology, 32(4), 378-391 (2018-03-12)
Whether oral anticoagulants, vitamin K antagonists (VKAs), and nonvitamin K oral anticoagulant (NOACs) frequently prescribed to atrial fibrillation (AF) patients, do themselves have a pro- or anti-arrhythmic effect have never been addressed. Transmembrane action potentials were recorded in an acute
Xuejie Chen et al.
Blood, 132(18), 1974-1984 (2018-08-10)
Warfarin, acenocoumarol, phenprocoumon, and fluindione are commonly prescribed oral anticoagulants for the prevention and treatment of thromboembolic disorders. These anticoagulants function by impairing the biosynthesis of active vitamin K-dependent coagulation factors through the inhibition of vitamin K epoxide reductase (VKOR).
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