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Merck
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文件

SML3191

Sigma-Aldrich

Cotrimoxazole

≥98% (HPLC)

别名:

4-Amino-N-(5-methyl-3-isoxazolyl)-benzenesulfonamide mixt. with 5-[(3,4,5-trimethoxyphenyl)methyl]-2,4-pyrimidinediamine, TMP/SMX, Trimethoprim/sulfamethoxazole

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About This Item

经验公式（希尔记法）:
C14H18N4O3·5C10H11N3O3S
CAS号:
8064-90-2
分子量:
1556.71
分類程式碼代碼:
12352107
NACRES:
NA.77

品質等級

100

化驗

≥98% (HPLC)

形狀

powder

顏色

white to beige

溶解度

DMSO: 2 mg/mL, clear

儲存溫度

−20°C

InChI

1S/C14H18N4O3.C10H11N3O3S/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15;1-7-6-10(12-16-7)13-17(14,15)9-4-2-8(11)3-5-9/h5-7H,4H2,1-3H3,(H4,15,16,17,18);2-6H,11H2,1H3,(H,12,13)

InChI 密鑰

WZRJTRPJURQBRM-UHFFFAOYSA-N

生化／生理作用

Cotrimoxazole is a combination antibiotic consisting of one part trimethoprim to five parts sulfamethoxazole that is used to treat a variety of bacterial infections both Gram-positive and Gram-negative. Sulfamethoxazole inhibits bacterial dihydropteroate synthase while trimethoprim inhibits bacterial dihydrofolate reductase, thereby blocking the synthesis of nucleic acids.

象形圖

Health hazardExclamation mark
GHS08,GHS07

訊號詞

Warning

危險聲明

H302,H361d

危險分類

Acute Tox. 4 Oral - Repr. 2

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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Nathan Ford et al.
Journal of acquired immune deficiency syndromes (1999), 66(5), 512-521 (2014-05-24)
Cotrimoxazole is widely prescribed to treat a range of infections, and for HIV-infected individuals it is administered as prophylaxis to protect against opportunistic infections. Some reports suggest that fetuses exposed to cotrimoxazole during early pregnancy may have an increased risk

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