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生化／生理作用
A-395是针对聚梳蛋白EED（胚胎外胚层发育）的一种有效的选择性化学探针，而EED是聚梳抑制复合物2（PRC2）的重要组成部分，可通过组蛋白H3K27的甲基化参与转录抑制。已发现A-395在体外可以0.4 nM的Ki值与EED结合，而抑制PRC2复合物进行H3K27甲基化的IC50值为34 nM，并比其他组蛋白甲基转移酶和非表观遗传靶标具有>100倍的选择性 。在RD横纹肌瘤细胞系中，A-395可抑制PRC2复合物，IC50值为90 nM，从而抑制H3K27me3的形成。有关 A-395的表征详细信息，请访问 Structural Genomics Consortium (SGC) 网站上的 A-395 探针摘要 。
A-395N是活性对映体A-395的阴性对照。A-395N可从Sigma获得。如需了解更多并购买A-395N，请点击此处。
想要了解用于表观遗传靶标的其他 SGC 化学探针，请访问 sigma.com/sgc
A-395N是活性对映体A-395的阴性对照。A-395N可从Sigma获得。如需了解更多并购买A-395N，请点击此处。
想要了解用于表观遗传靶标的其他 SGC 化学探针，请访问 sigma.com/sgc
特點和優勢
A-395是一种表观遗传化学探针，通过与Structural Genomics Consortium（SGC）合作开发。想要了解更多信息并查看其他SGC表观遗传探针，请访问sigma.com/SGC。
訊號詞
Danger
危險聲明
危險分類
Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2
儲存類別代碼
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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