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Merck

SML1073

Sigma-Aldrich

BIX

≥98% (HPLC)

别名:

2-(3,4-二羟基苯基)-2-氧乙基酯硫氰酸, BiP蛋白诱导剂X

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About This Item

经验公式(希尔记法):
C9H7NO3S
分子量:
209.22
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

品質等級

化驗

≥98% (HPLC)

形狀

powder

顏色

white to beige

溶解度

DMSO: 20 mg/mL, clear

儲存溫度

2-8°C

SMILES 字串

OC1=C(O)C=C(C(CSC#N)=O)C=C1

InChI

1S/C9H7NO3S/c10-5-14-4-9(13)6-1-2-7(11)8(12)3-6/h1-3,11-12H,4H2

InChI 密鑰

SVFLBLCWKKQKDW-UHFFFAOYSA-N

應用

BIX已被用于细胞活力检测。

生化/生理作用

BIX(BiP蛋白诱导因子X)可诱导内质网伴侣蛋白GRP78(葡萄糖调节蛋白78,BiP)的表达,导致未折叠蛋白应答的减弱。 BIX可保护神经元细胞和视网膜细胞免受内质网应激诱导的细胞死亡。

其他說明

空气敏感

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Skin Sens. 1

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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X Xie et al.
Current molecular medicine, 18(1), 3-14 (2018-03-27)
Vascular network formation induced by angiogenesis plays an important role in many physiological and pathological processes. However, the role of blood flow and underlying mechanisms in vascular network formation, for example for the development of the caudal vein plexus (CVP)
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Several intervention studies have demonstrated that exercise training has beneficial effects among cancer patients. However, older cancer patients are underrepresented in clinical trials, and only few exercise-based studies have focused specifically on older patients with cancer. In particular, research investigating the
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Circulation, 142(25), 2443-2455 (2020-10-24)
Ibrutinib is a Bruton tyrosine kinase inhibitor with remarkable efficacy against B-cell cancers. Ibrutinib also increases the risk of atrial fibrillation (AF), which remains poorly understood. We performed electrophysiology studies on mice treated with ibrutinib to assess inducibility of AF.
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Genome research, 27(9), 1487-1500 (2017-06-10)
To understand disease mechanisms, a large-scale analysis of human-yeast genetic interactions was performed. Of 1305 human disease genes assayed, 20 genes exhibited strong toxicity in yeast. Human-yeast genetic interactions were identified by en masse transformation of the human disease genes
Dana M Hardbower et al.
Proceedings of the National Academy of Sciences of the United States of America, 114(5), E751-E760 (2017-01-18)
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