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Merck
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Key Documents

SML0684

Sigma-Aldrich

SF1670

≥98% (HPLC)

别名:

N-(9,10-Dihydro-9,10-dioxo-2-phenanthrenyl)-2,2-dimethyl-propanamide, N-(9,10-Dioxo-9,10-dihydro-phenanthren-2-yl)-2,2-dimethylpropionamide

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About This Item

经验公式（希尔记法）:
C19H17NO3
CAS号:
345630-40-2
分子量:
307.34
分類程式碼代碼:
12352200
NACRES:
NA.77

化驗

≥98% (HPLC)

形狀

powder

顏色

, light pink to red to very dark purple

溶解度

DMSO: 10 mg/mL, clear

儲存溫度

2-8°C

InChI

1S/C19H17NO3/c1-19(2,3)18(23)20-11-8-9-13-12-6-4-5-7-14(12)16(21)17(22)15(13)10-11/h4-10H,1-3H3,(H,20,23)

InChI 密鑰

VZQDDSYKVYARDW-UHFFFAOYSA-N

應用

SF1670 has been used:
  • To study the effect of microRNA-30a on PTEN (phosphatase and tensin homologue deleted on chromosome 10 ) expression regulation.
  • To study the formation of autophagosomes, induced by EGF (Epidermal growth factor) - dependent PTEN expression.
  • To study the role of PTEN in the regulation of autophagy induction in human normal endometrial stromal cells.

生化／生理作用

PTEN prevents PI3-K(phosphoinositide 3-kinase)/Akt signaling pathway, which is very essential for neuronal regeneration. Therefore, inhibition of PTEN by SF1670 may support neuronal regeneration.
SF1670 is a selective PTEN (phosphatase and tensin homolog) inhibitor with an IC50 of 2 micromolar. PTEN inhibition by SF1670 was shown to increase neutrophil activity (polarization, phagocytosis, oxidative burst, and recruitment to site of infection), thereby enhancing the inflammatory response and bacteria-killing capacity of neutopenic mice.

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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LY-294,002 盐酸盐 solid, ≥98% (HPLC)

Sigma-Aldrich

L9908

LY-294,002 盐酸盐

Bioinformatics prediction of miR-30a targets and its inhibition of cell proliferation of osteosarcoma by up-regulating the expression of PTEN.
Zhong B, et al.
BMC Medical Genomics, 10(1), 64-64 (2017)
PTEN inhibition to facilitate intrinsic regenerative outgrowth of adult peripheral axons.
Christie K J, et al.
The Journal of Neuroscience, 30(27), 9306-9315 (2010)
Paradoxical induction of growth arrest and apoptosis by EGF via the up-regulation of PTEN by activating Redox factor-1/Egr-1 in human lung cancer cells.
Ryu J W, et al.
Oncotarget, 8(3), 4181-4181 (2017)
Stefanie Kälin et al.
Cell metabolism, 26(3), 475-492 (2017-09-07)
Obesity and type 2 diabetes are associated with metabolic defects and adipose tissue inflammation. Foxp3
Aberrant PTEN expression in response to progesterone reduces endometriotic stromal cell apoptosis.
Choi J, et al.
Reproduction (Cambridge, England), 153(1), 11-21 (2017)
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