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product name
弗林蛋白酶抑制剂 II,
化驗
≥95% (HPLC)
形狀
lyophilized
成份
Peptide Content, ≥48%
儲存條件
protect from light
技術
protein extraction: suitable
儲存溫度
−20°C
Amino Acid Sequence
Mpa-Mpa-Mpa-Mpa-Mpa-Mpa
一般說明
弗林蛋白酶是一种钙依赖性丝氨酸内蛋白酶，属于枯草杆菌蛋白酶样前蛋白/激素转换酶（PC）家族。它分布广泛，并且可在反式高尔基网络、细胞表面和内体之间有节规律的移动。
應用
弗林蛋白酶抑制剂II已作为弗林蛋白酶抑制剂用于：
- 研究在非致瘤性永生化人类颗粒细胞系（SVOG）中，其对转化生长因子β1（TGF-β1） 诱导的神经胶质细胞系衍生的神经营养因子（GDNF）产生的影响。
- 研究其对人肾2（HK-2）细胞中牛血清白蛋白（BSA）诱导的肾素（原）受体（PRR）裂解的作用。
- 用于弗林蛋白酶裂解试验中。
生化／生理作用
弗林蛋白酶在几种前蛋白的加工中起作用，例如骨形态发生蛋白4（BMP-4）、胰岛素受体和Notch1受体。它还可以处理人类免疫缺陷病毒1（HIV-1）糖蛋白gp160、几种金属蛋白酶、以及β-神经增长因子前体（β-NGF前体）。弗林蛋白酶还可参与转化生长因子 β1（TGF-β1）的裂解。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
其他客户在看
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The Journal of Biological Chemistry, 275(47), 36741-36749 (2000)
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Glypican-3 (GPC3) is a surface-bound proteoglycan overexpressed in pediatric liver cancer and utilized clinically as an immunohistochemical tumor marker. Furin is a proprotein convertase that is ubiquitously expressed and shown to modify GPC3 post-translationally. In experimental models of epithelial-based cancers
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Glial cell line-derived neurotrophic factor (GDNF) is expressed at a high level in the human ovary and GDNF signaling is involved in the direct control of follicular activation and oocyte maturation. Transforming growth factor-β1 (TGF-β1) plays an important role in
Evidence that furin is an authentic transforming growth factor-beta1-converting enzyme
Dubois C M, et al.
The American Journal of Pathology, 158(1), 305-316 (2001)
C M Dubois et al.
The American journal of pathology, 158(1), 305-316 (2001-01-06)
Transforming growth factor (TGF)-beta1 plays an essential role in cell growth and differentiation. It is also considered as a gatekeeper of immune homeostasis with gene disruption leading to autoimmune and inflammatory diseases. TGF-beta1 is produced as an inactive precursor polypeptide
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