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生物源
rabbit
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
物種活性
rat, human, canine
技術
immunoblotting: suitable
immunofluorescence: suitable
immunohistochemistry: suitable
UniProt登錄號
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... CLDN4(1364)
一般說明
Claudin-4 is heterogeneously expressed in various tissues. It is enriched in endothelial cells (ECs), including the blood-brain barrier, and is also expressed in gut and kidney. It is mapped to human chromosome 7q11.23. Claudin-4 is associated with the tight junction strands in kidney epithelial cells.
特異性
Anti-Claudin-4 (C-terminal) specifically recognizes human, rat and dog claudin-4.
應用
Anti-Claudin-4 (C-terminal) antibody produced in rabbit has been used in:
- immunoblotting
- immunofluorescence
- immunohistochemistry
生化／生理作用
Claudin-4 is involved in maintaining cellular polarity. It favors sodium chloride absorption and acts as a cation-barrier. Claudin-4 expression has been shown to be deregulated in several cancers, with aberrant expression in ovarian, breast, prostate and pancreatic carcinomas. The gene location of claudin-4 is a Williams-Beuren syndrome critical region.
外觀
Supplied as a solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
儲存和穩定性
For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Williams-Beuren syndrome: a challenge for genotype-phenotype correlations
Tassabehji, M
Human Molecular Genetics, 12, R229-R237 (2003)
Clinical utility gene card for: Williams-Beuren Syndrome [7q11. 23]
Koehler U, et al.
European Journal of Human Genetics, 22(9), 1153-1153 (2014)
Claudin-1,-2,-4, and-5: comparison of expression levels and distribution in equine tissues
Lee B, et al.
Journal of Veterinary Science, 17(4), 445-451 (2016)
Claudin-3 and claudin-4 expression in ovarian epithelial cells enhances invasion and is associated with increased matrix metalloproteinase-2 activity
Agarwal R, et al.
Cancer Research, 65(16), 7378-7385 (2005)
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