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生物源
rabbit
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen ~43 kDa
物種活性
mouse, human
濃度
~1.0 mg/mL
技術
indirect immunofluorescence: 1-2 μg/mL using HeLa cells
western blot: 1-2 μg/mL using HepG2 and A431 cell lysates
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
phosphorylation (pSer409)
基因資訊
human ... TARDBP(23435)
mouse ... Tardbp(230908)
一般說明
Transactive response DNA-binding protein 43 (TDP-43) belongs to the family of heterogeneous nuclear ribonucleoproteins (hnRNPs). It has two RNA-recognition motifs and a glycine-rich C-terminal sequence. TDP-43 is expressed in heart, lung, liver and brain, which is localized to the nucleus..
免疫原
synthetic peptide containing phosphorylated Ser409 of human TDP-43 conjugated to KLH. The corresponding sequence is identical in mouse TDP-43
應用
Anti-phospho-TDP-43 [pSer409] antibody produced in rabbit has been used in:
- enzyme linked immuno sorbent assay (ELISA)
- immunohistochemistry
- immunoblotting
- immunofluorescence
生化／生理作用
Transactive response DNA-binding protein 43 (TDP-43) binds to single stranded RNA. It regulates transcription regulation in human immunodeficiency virus (HIV). TDP-43 is the major ubiquinated component of cytoplasmic inclusions in frontotemporal lobe degeneration subtype (FTLD-U) and amyotrophic lateral sclerosis (ALS). Pathological TDP-43 forms abnormal inclusions in neuronal perikarya and neurites. Mutations in TDP-43 is associated with ALS. Abnormal phosphorylation of TDP-43 at Ser409/410 is observed in FTLD-U and ALS, leading to apoptosis.
外觀
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Yuting Ren et al.
Frontiers in neurology, 12, 663637-663637 (2021-07-02)
Objective: The aim of this study was to measure both plasma and cerebrospinal fluid (CSF) TAR DNA-binding protein 43 (TDP-43) and phosphorylated TDP-43 (pTDP-43) levels in sporadic amyotrophic lateral sclerosis (sALS) patients, and to compare them with that of healthy
TDP-43-mediated neurodegeneration: towards a loss-of-function hypothesis?
Broeck LV, et al.
Trends in Molecular Medicine, 20(2), 66-71 (2014)
Retrotransposon activation contributes to neurodegeneration in a Drosophila TDP-43 model of ALS
Krug L, et al.
PLoS Genetics, 13(3), e1006635-e1006635 (2017)
Emily Feneberg et al.
Molecular neurobiology, 55(10), 7789-7801 (2018-02-21)
TDP-43 accumulates in nerve cells of nearly all cases of amyotrophic lateral sclerosis (ALS; the commonest form of motor neuron disease) and in the majority of Tau-negative frontotemporal lobar degeneration (FTLD). There is currently no biochemical test or marker of
Lisa Krug et al.
PLoS genetics, 13(3), e1006635-e1006635 (2017-03-17)
Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are two incurable neurodegenerative disorders that exist on a symptomological spectrum and share both genetic underpinnings and pathophysiological hallmarks. Functional abnormality of TAR DNA-binding protein 43 (TDP-43), an aggregation-prone RNA and
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