推荐产品
生物源
rabbit
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen ~55 kDa
包裝
antibody small pack of 25 μL
濃度
~1.5 mg/mL
技術
indirect immunofluorescence: 5-10 μg/mL using NIH3T3 cells
western blot: 1.5-3.0 μg/mL using A431 cell extract
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... CORO1C(23603)
mouse ... Coro1c(23790)
rat ... Coro1c(501841)
一般說明
Coronin-1C (also known as CORO1C, Coronin-3, HCRNN4) belongs to the coronin family of tryptophan-aspartic acid (WD) 40 repeat-containing proteins. Coronin-1C is ubiquitously expressed and co-localizes with F-actin. In fibroblasts, CORO1C is localized both in the cytosol and in the submembrane cytoskeleton, especially at lamellipodia and membrane ruffles.
應用
Anti-Coronin-1C (C-terminal) antibody produced in rabbit has been used in immunoblotting and immunofluorescence.
生化／生理作用
Coronins appear to function primarily in association with the membrane cytoskeleton through interaction with F-actin and the actin-related protein (Arp2/3) complex. They localize to submembrane areas and regulate cell motility and cytoskeletal rearrangement. important in cytokinesis, cell motility, endocytosis, axonal growth, wound healing and signal transduction by altering actin dynamics. Coronin-1C is abundantly expressed in the central nervous system (CNS) during embryogenesis and first postnatal stages and in primary oligodendrocytes.
外觀
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Coronin 3 and its role in murine brain morphogenesis
Hasse A, et al.
The European Journal of Neuroscience, 21(5), 1155-1168 (2005)
Isolation and chromosomal assignment of a novel human gene, CORO1C, homologous to coronin-like actin-binding proteins
Iizaka M, et al.
Cytogenetic and genome research, 88(3-4), 221-224 (2000)
Coronin proteins as multifunctional regulators of the cytoskeleton and membrane trafficking
Rybakin V and Clemen CS
Bioessays, 27(6), 625-632 (2005)
Oligomerization, F-actin interaction, and membrane association of the ubiquitous mammalian coronin 3 are mediated by its carboxyl terminus
Spoerl Z, et al.
The Journal of Biological Chemistry, 277(50), 48858-48867 (2002)
Coronin 3 involvement in F-actin-dependent processes at the cell cortex
Rosentreter A, et al.
Experimental Cell Research, 313(5), 878-895 (2007)
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