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S3572

Sigma-Aldrich

甜叶菊甙元

from Stevia sp., ≥98% (HPLC), powder, p-aminohippurate transepithelial transport inhibitor

别名:

(4α-13-[(2-O-β-D-吡喃葡萄糖基-β-D-吡喃葡萄糖基)氧基]贝壳杉-16-烯-18-酸-β-D-吡喃葡萄糖酯

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About This Item

经验公式（希尔记法）:
C38H60O18 · xH2O
CAS号:
57817-89-7
分子量:
804.87 (anhydrous basis)
分類程式碼代碼:
12352200
PubChem物質ID:
329824534
NACRES:
NA.77

product name

甜叶菊甙元, ≥98% (HPLC)

生物源

Stevia sp.

化驗

≥98% (HPLC)

形狀

powder

顏色

white

溶解度

DMSO: 25 mg/mL, clear

儲存溫度

2-8°C

SMILES 字串

O.C[C@@]12CCC[C@](C)(C1CC[C@]34CC(=C)[C@](CCC23)(C4)O[C@@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O[C@@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@H]6O)C(=O)O[C@@H]7O[C@H](CO)[C@@H](O)[C@H](O)[C@H]7O

InChI

1S/C38H60O18.H2O/c1-16-11-37-9-5-20-35(2,7-4-8-36(20,3)34(50)55-32-29(49)26(46)23(43)18(13-40)52-32)21(37)6-10-38(16,15-37)56-33-30(27(47)24(44)19(14-41)53-33)54-31-28(48)25(45)22(42)17(12-39)51-31;/h17-33,39-49H,1,4-15H2,2-3H3;1H2/t17-,18-,19-,20+,21+,22-,23-,24-,25+,26+,27+,28-,29-,30-,31+,32+,33+,35-,36-,37-,38+;/m1./s1

InChI 密鑰

FVECWZKNZGXJJO-QMYNVHDOSA-N

相关类别

應用

已在人乳腺癌细胞中研究了甜菊糖诱导的ROS介导的细胞凋亡。
甜菊苷水合物已被用作高效液相色谱（HPLC）法定量测定甜菊糖苷的标准品。

生化／生理作用

据报道，甜菊糖在培养哺乳动物细胞时具有遗传毒性作用。
甜菊糖是一种无热量的天然甜味剂，甜度比蔗糖高 300 倍。它通过干扰有机阴离子转运系统而抑制对氨基马尿酸盐 (PAH) 的跨上皮转运。在 0.5-1 mM 时，它与任何有机阴离子转运蛋白（OAT）均无相互作用。
甜菊苷水合物是存在于甜叶菊中的二萜糖苷。

準備報告

应在DMSO中制备甜菊糖溶液。高纯度甜菊糖的水溶性非常差。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves

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M Matsui et al.
Mutagenesis, 11(6), 573-579 (1996-11-01)
Stevioside, a constituent of Stevia rebaudiana, is commonly used as a non-caloric sugar substitute in Japan. The genetic toxicities of stevioside and its aglycone, steviol, were examined with seven mutagenicity tests using bacteria (reverse mutation assay, forward mutation assay, umu
Tadamasa Terai et al.
Chemical & pharmaceutical bulletin, 50(7), 1007-1010 (2002-07-20)
Stevioside is natural non-caloric sweetner isolated from Stevia rebaudiana BERTONI, which has been used as a non-caloric sugar substitute in Japan. Pezzuto et al. demonstrated that steviol shows a dose-dependent positive response in forward mutation assay using Salmonella typhimurium TM677
Evaluation of the euglycemic effect of oral administration of S. rebaudiana B. cultivated in Mexico in normoglycemic and induced-diabetic rats
Irma AG, et al.
International journal of environment, agriculture and biotechnology, 2(1) null
Determination of rebaudioside A and Stevioside in leaves of S. rebaudiana Bertoni grown in Mexico by a validated HPLC method
Aranda-Gonzalez I, et al.
American Journal of Analytical Chemistry, 6(11), 878-878 (2015)
J M Pezzuto et al.
Proceedings of the National Academy of Sciences of the United States of America, 82(8), 2478-2482 (1985-04-01)
Stevioside, a constituent of Stevia rebaudiana, is commonly used as a noncaloric sugar substitute in Japan. Consistent with reports in the literature, we have found that stevioside is not mutagenic as judged by utilization of Salmonella typhimurium strain TM677, either
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