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Merck
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文件

P7208

Sigma-Aldrich

Pertussis toxin

from Bordetella pertussis, lyophilized powder, protein endotoxin

别名:

IAP, PTX, 百日咳杆菌属, 组胺敏化因子, 胰岛活化蛋白

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About This Item

CAS号:
70323-44-3
MDL號碼:
MFCD00131841
分類程式碼代碼:
12352200
NACRES:
NA.77

product name

百日咳毒素 来源于百日咳杆菌, lyophilized powder

形狀

lyophilized powder

品質等級

200

儲存溫度

2-8°C

基因資訊

Bordetella pertussis Tohama I ... ptxA(2665068) , ptxB(2665069) , ptxC(2665408)

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一般說明

百日咳毒素(PT)是由1个活性亚基(A)和5个结合亚基(B5)组成的多亚基复合物毒素。百日咳毒素通过结合细胞表面糖基化分子经由内吞作用进入哺乳动物细胞。

應用

百日咳毒素（来自百日咳鲍特菌）用途：作为趋化因子(CXCR4)受体Gαi亚基的抑制剂，用于检测乳腺癌细胞系中的胞内Ca2+，用于分析参与ADP诱导的组织因子(TF)和P-选择素暴露的Gi信号传导，用于诱导大鼠模型的自身免疫血管炎
该毒素是以无活性形式由百日咳博德特氏菌释放的。当百日咳毒素B寡聚物结合到细胞膜上时，其A原聚体的S1亚基会被激活，这可能是通过谷胱甘肽和ATP的作用而实现的。 在体外激活百日咳毒素的实验方法是由Kaslow等提供的。

生化／生理作用

百日咳毒素可催化异三聚体鸟嘌呤核苷酸调节蛋白Gi、Go和Gt的α亚基的ADP-核糖基化。 这可防止G蛋白异源三聚体与受体的相互作用，从而阻止其偶联和激活。 由于Gα亚基仍处于与GDP结合的非活性状态，因此它们无法使腺苷酸环化酶失活或打开K+通道。

特點和優勢

《受体分类和信号转导》手册的 G蛋白（三聚体） 页面有该化合物的介绍。想要浏览手册的其他页面， 请单击此处。
该化合物是环核苷酸研究推荐产品。点击此处 ，查看更多环核苷酸精选产品。想要了解有关生物活性小分子在其他研究领域应用的更多信息，请访问 sigma.com/discover-bsm。

外觀

含氯化钠和磷酸钠缓冲盐的冻干粉

象形圖

Exclamation mark
GHS07

訊號詞

Warning

危險聲明

H315,H319,H335

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

13 - Non Combustible Solids

水污染物質分類（WGK）

WGK 2

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Wendy Atkinson et al.
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An alternative hypothesis has been proposed implicating chronic cerebrospinal venous insufficiency (CCSVI) as a potential cause of multiple sclerosis (MS). We aimed to evaluate the validity of this hypothesis in a controlled animal model. Animal experiments were approved by the
Mary J Mattapallil et al.
Journal of autoimmunity, 102, 65-76 (2019-05-14)
IL-22 has opposing effects in different tissues, from pro-inflammatory (skin, joints) to protective (liver, intestine) but little is known about its effects on neuroinflammation. We examined the effect of IL-22 on retinal tissue by using the model of experimental autoimmune
Orr Ofek et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 26(2), 308-316 (2010-08-31)
CB2 is a Gi protein-coupled receptor activated by endo- and phytocannabinoids, thus inhibiting stimulated adenylyl cyclase activity. CB2 is expressed in bone cells and Cb2 null mice show a marked age-related bone loss. CB2-specific agonists both attenuate and rescue ovariectomy-induced
Takashi Hosokawa et al.
Journal of immunology (Baltimore, Md. : 1950), 199(6), 2008-2019 (2017-08-05)
Mechanistic target of rapamycin complex (mTORC)1 integrates intracellular sufficiency of nutrients and regulates various cellular functions. Previous studies using mice with conditional knockout of mTORC1 component proteins (i.e., mTOR, Raptor, and Rheb) gave conflicting results on the roles of mTORC1
Nicholas H Carbonetti
Future microbiology, 5(3), 455-469 (2010-03-10)
Pertussis toxin and adenylate cyclase toxin are two important virulence factors of Bordetella pertussis, the bacterial cause of the respiratory disease pertussis or whooping cough. In addition to studies on the structure, function and role in pathogenesis of these two
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