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P4365

Sigma-Aldrich

PJ-34 盐酸盐 水合物

≥98% (HPLC), powder

别名:

PARP抑制剂VIII, PJ 34 HCl, N-(6-氧代-5,6-二氢菲啶-2-基)-(N,N-二甲基氨基)乙酰胺 盐酸盐

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About This Item

经验公式（希尔记法）:
C17H17N3O2 · HCl · xH2O
CAS号:
344458-15-7
分子量:
331.80 (anhydrous basis)
分類程式碼代碼:
12352200
PubChem物質ID:
24898531
NACRES:
NA.77

品質等級

100

化驗

≥98% (HPLC)

形狀

powder

儲存條件

desiccated

顏色

white to yellow

溶解度

H2O: 22 mg/mL

SMILES 字串

Cl[H].[H]O[H].CN(C)CC(=O)Nc1ccc2NC(=O)c3ccccc3-c2c1

InChI

1S/C17H17N3O2.ClH.H2O/c1-20(2)10-16(21)18-11-7-8-15-14(9-11)12-5-3-4-6-13(12)17(22)19-15;;/h3-9H,10H2,1-2H3,(H,18,21)(H,19,22);1H;1H2

InChI 密鑰

YCALIZUKAFUQCH-UHFFFAOYSA-N

應用

PJ-34盐酸盐水合物用于：
  • 作为聚（ADP-核糖）聚合酶(PARP)抑制剂1，测试PAPR1对大鼠神经性疼痛的作用
  • 作为蛋白质提取缓冲液的组分，可视化各种细胞样本中中PARylated蛋白质的高分子量涂片
  • 作为小鼠MLE-12上皮细胞系的PARP抑制剂

生化／生理作用

PJ-34是一种原型聚（ADP-核糖）聚合酶1 (PARP-1)抑制剂。
PJ-34是一种强效聚(ADP-核糖)聚合酶（PARP）抑制剂。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

分析证书(COA)

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Garcia Soriano F et al.
Nature medicine, 7(1), 108-113 (2001-01-03)
Diabetic patients frequently suffer from retinopathy, nephropathy, neuropathy and accelerated atherosclerosis. The loss of endothelial function precedes these vascular alterations. Here we report that activation of poly(ADP-ribose) polymerase (PARP) is an important factor in the pathogenesis of endothelial dysfunction in
Hai-yan Li et al.
Acta pharmacologica Sinica, 35(4), 496-503 (2014-03-19)
Daidzein (4',7-dihydroxyisoflavone) is an isoflavone exiting in many herbs that has shown anti-inflammation activity. The aim of this study was to investigate the mechanism underlying its anti-inflammatory action in murine lung epithelial cells. C57BL/6 mice were intranasally exposed to TNF-α
Yan Gao et al.
Brain, behavior, and immunity, 88, 482-496 (2020-04-14)
Emerging evidence has implicated poly-(ADP-ribose) polymerase 1 (PARP-1), a transcriptional coregulator, in a variety of inflammatory diseases. In the current study, the role of PARP-1 in neuropathic pain and the underlying mechanisms were investigated. Neuropathic pain was determined by assessing
Mohamad El Amki et al.
Molecular neurobiology, 55(12), 9156-9168 (2018-04-14)
Benefits from thrombolysis with recombinant tissue plasminogen activator (rt-PA) after ischemic stroke remain limited due to a narrow therapeutic window, low reperfusion rates, and increased risk of hemorrhagic transformations (HT). Experimental data showed that rt-PA enhances the post-ischemic activation of
G E Abdelkarim et al.
International journal of molecular medicine, 7(3), 255-260 (2001-02-17)
Focal cerebral ischemia activates the nuclear protein poly(ADP-ribose) polymerase (PARP) by single DNA strand breaks which leads to energy depletion and cell necrosis. Deletion or inhibition of PARP protects against ischemic brain injury. Here we examined the neuroprotective effect of
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