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Merck
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文件

M4659

Sigma-Aldrich

米力农

≥97% (TLC), powder, phosphodiesterase type III inhibitor

别名:

1,6-二氢-2-甲基-6-氧-（3,4′-联吡啶）-5-甲腈

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About This Item

经验公式（希尔记法）:
C12H9N3O
CAS号:
78415-72-2
分子量:
211.22
EC號碼:
278-903-6
MDL號碼:
MFCD00133539
分類程式碼代碼:
41106305
PubChem物質ID:
24278060
NACRES:
NA.77

product name

米力农, ≥97% (TLC), powder

品質等級

200

化驗

≥97% (TLC)

形狀

powder

顏色

off-white

溶解度

DMSO: >10 mg/mL
H2O: insoluble

起源

Sanofi Aventis

儲存溫度

2-8°C

SMILES 字串

CC1=C(C=C(C#N)C(=O)N1)c2ccncc2

InChI

1S/C12H9N3O/c1-8-11(9-2-4-14-5-3-9)6-10(7-13)12(16)15-8/h2-6H,1H3,(H,15,16)

InChI 密鑰

PZRHRDRVRGEVNW-UHFFFAOYSA-N

基因資訊

human ... PDE3A(5139) , PDE3B(5140) , PDE4B(5142) , PDE5A(8654) , PTPRA(5786)
rat ... Pde3a(50678)

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生化／生理作用

磷酸二酯酶 Ⅲ 型抑制剂；cAMP 特异性、cGMP 抑制性；强心、正性肌力血管扩张剂。

特點和優勢

该化合物是受体分类及信号转导手册上磷酸二酯酶页面上的特色化合物。想要浏览手册的其他页面， 请单击此处。
该化合物是环核苷酸研究推荐产品。点击此处 ，查看更多环核苷酸精选产品。想要了解有关生物活性小分子在其他研究领域应用的更多信息，请访问 sigma.com/discover-bsm。
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象形圖

Skull and crossbones
GHS06

訊號詞

Danger

危險聲明

H301

危險分類

Acute Tox. 3 Oral

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

分析证书(COA)

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Dirk Bassler et al.
The Cochrane database of systematic reviews, (11)(11), CD007802-CD007802 (2010-11-12)
Persistent pulmonary hypertension of the newborn (PPHN) is a clinical syndrome characterized by suboptimal oxygenation as a result of sustained elevation in pulmonary vascular resistance after birth. Currently, the therapeutic mainstay for PPHN is optimal lung inflation and selective vasodilatation
Baozeng Xu et al.
Developmental biology, 385(2), 242-252 (2013-11-20)
The oocyte becomes competent for embryonic development by involving mutual communication with cumulus cells (CCs) during folliculogenesis. How this communication takes place under physiological conditions is not fully understood. Current study examined oocyte-CCs communication in the XY sex-revered female mouse.
Maria Otilia Bianchi et al.
Shock (Augusta, Ga.), 44(2), 115-120 (2015-04-22)
Despite the advancement in the postoperative care of neonates with congenital heart disease (CHD), there is little information on preoperative management of systemic and regional hemodynamics, which may be related to outcomes. We aimed to determine the preoperative effect of
Jerrold H Levy et al.
The Annals of thoracic surgery, 73(1), 325-330 (2002-02-09)
Phosphodiesterase inhibitors including milrinone produce positive inotropic effects by slowing the hydrolysis of cyclic adenosine monophosphate in the myocardium. With a loading dose of 50 microg/kg followed by an infusion of 0.5 microg x kg(-1) x min(-1), milrinone increases stroke
Afif F El-Khuffash et al.
The Journal of pediatrics, 165(1), 46-52 (2014-05-13)
To compare differences in tissue Doppler imaging, global longitudinal strain (GLS), and cardiac troponin T (cTnT) between infants with low (<200 mL/kg/min) and high (>200 mL/kg/min) left ventricular (LV) output 1 hour after duct ligation and assess the impact of
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