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Merck
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文件

I1771

Sigma-Aldrich

Interleukin-13 human

≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

别名:

IL-13

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About This Item

CAS号:
148157-34-0
MDL號碼:
MFCD00212209
分類程式碼代碼:
12352202
NACRES:
NA.32

生物源

human

品質等級

200

重組細胞

expressed in E. coli

化驗

≥97% (SDS-PAGE)

形狀

lyophilized powder

效力

<10.000 ng/mL ED50

分子量

12 kDa

包裝

pkg of 10 μg

技術

cell culture | mammalian: suitable

雜質

endotoxin, tested

顏色

white

UniProt登錄號

P35225

儲存溫度

−20°C

基因資訊

human ... IL13(3596)

相关类别

生化／生理作用

IL-13 is known to be overexpressed in glioblastoma tumors and cell lines. Elevated IL-13 expression is also observed in parasitic infections. It stimulates fibrosis in many infectious diseases, and acts as a profibrogenic factor.
Interleukin-13 is a pleiotropic cytokine produced by activated Th2 cells in the mouse and human. IL-13 is secreted mainly as an unglycosylated protein of 132 amino acids with a molecular weight of 10,000 daltons. A 4.3kb DNA fragment of the mouse IL-13 gene was sequenced and occurs as a single copy mapping a chromosome 11. In the human, a 4.6 kb DNA segment of the IL-13 gene occurs as a single copy and maps to chromosome 5. IL-13 induces B cell proliferation and also induces IgE switching. The proliferative activity of human and mouse IL-13 products are tested in culture using the human erythroleukemic cell line TF-1.

外觀

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 250 μg BSA.

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

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Ji-Yun Lee et al.
Journal of immunology (Baltimore, Md. : 1950), 194(12), 5990-5998 (2015-05-15)
Mucin overproduction is a hallmark of otitis media (OM). Streptococcus pneumoniae is one of the most common bacterial pathogens causing OM. Mucin MUC5AC plays an important role in mucociliary clearance of bacterial pathogens. However, if uncontrolled, excessive mucus contributes significantly
An IL-13 promoter polymorphism associated with liver fibrosis in patients with Schistosoma japonicum.
Long X et al
PLoS ONE, 10(8), e0135360-e0135360 (2015)
Kihyuk Shin et al.
Clinical and experimental medicine, 15(3), 233-244 (2014-06-14)
The leukotrienes (LTs) enhance allergen- and interleukin (IL)-13-dependent allergic lung inflammatory disease. However, the precise requirement of LTs and the mechanism by which they elicit allergic lung responses remain uncertain. To clarify the involvement of LTs in respiratory allergen- and
Gui Yang et al.
The Journal of biological chemistry, 290(20), 12858-12867 (2015-04-04)
Restoration of the antigen (Ag)-specific immune tolerance in an allergic environment is refractory. B cells are involved in immune regulation. Whether B cells facilitate the generation of Ag-specific immune tolerance in an allergic environment requires further investigation. This paper aims
Qi Liu et al.
The Journal of heart valve disease, 24(4), 496-501 (2016-02-24)
Interleukin (IL)-13 is a major inducer of fibrosis in many chronic infectious diseases, yet few studies have reported its role in valvular fibrosis in patients with rheumatic heart disease (RHD). The study aim was to investigate the role of IL-13
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