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H6291

Sigma-Aldrich

IL-1β human

HumanKine®, recombinant, Xeno-free, >95% (SDS-PAGE), suitable for cell culture

别名:

IL-1β, 淋巴细胞激活因子

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About This Item

MDL號碼:
MFCD00131399
分類程式碼代碼:
12352202
NACRES:
NA.77

product name

白介素1β 人, IL-1β, recombinant, expressed in HEK 293 cells, HumanKine®, suitable for cell culture, endotoxin tested

生物源

human

品質等級

100

重組細胞

expressed in HEK 293 cells

化驗

≥95% (SDS-PAGE)

形狀

lyophilized powder

效力

≤0.05 ng/mL EC50

品質

endotoxin tested

分子量

dimer 18-25 kDa (glycosylated)

包裝

pkg of 10 μg

技術

cell culture | mammalian: suitable

雜質

<1 EU/μg

UniProt登錄號

P01584

儲存溫度

−20°C

基因資訊

human ... IL1B(3553)

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生化／生理作用

白介素-1 (IL-1)，最初称为淋巴细胞激活因子(LAF)，可激活T细胞淋巴细胞，进而增殖并分泌白介素-2 (IL-2)。IL-1主要从受刺激的巨噬细胞和单核细胞释放，但也已显示可从几种其他类型细胞中释放，并且被认为在炎症和免疫应答中起关键作用。IL-1的其他同义词包括：内源性热原(EP)、有丝分裂原蛋白(MP)、辅助峰-1 (lp -1)、T细胞替代因子III（TRF III或TRFM）、B细胞激活因子(BAF)和B细胞分化因子(BDF)。两种关系紧密的试剂白细胞介素-1 α(IL-1α)和白细胞介素-1β (IL-1β)在氨基酸序列上有62%的同源性，引起几乎相同的生物反应。IL-1α和IL-1β的糖基化量都在17 kDa左右，具有一定的异质性。

外觀

从0.2 μm过滤的 1x PBS溶液中冻干。

準備報告

人源Kine重组人IL-1β在人HEK 293细胞中表达，是一种糖基化单体，分子量为18-25 kDa。在人HEK293细胞中生成可提供真正的糖基化。糖基化有助于细胞生长培养基和其他应用中的稳定性。

分析報告

通过小鼠D10S细胞增殖的剂量依赖性刺激测定活性。

法律資訊

HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

分析证书(COA)

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Charles A Dinarello et al.
Current opinion in endocrinology, diabetes, and obesity, 17(4), 314-321 (2010-07-01)
To understand the role of inflammation as the fundamental cause of type 2 diabetes and specifically to examine the contribution of IL-1beta. Recent studies from animals, in-vitro cultures and clinical trials provide evidence that support a causative role for IL-1beta
J O R Hernandez et al.
Nature communications, 12(1), 6496-6496 (2021-11-13)
The lack of animal models for some human diseases precludes our understanding of disease mechanisms and our ability to test prospective therapies in vivo. Generation of kidney organoids from Tuberous Sclerosis Complex (TSC) patient-derived-hiPSCs allows us to recapitulate a rare
Daniela Guidone et al.
JCI insight (2022-10-12)
The fluid covering the surface of airway epithelia represents a first barrier against pathogens. The chemical and physical properties of the airway surface fluid are controlled by the activity of ion channels and transporters. In cystic fibrosis (CF), loss of

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