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Merck

G1639

Sigma-Aldrich

D-(+)-半乳糖胺 盐酸盐

BioReagent, suitable for cell culture

别名:

2-氨基-2-脱氧-D-半乳糖 盐酸盐, D-软骨糖胺 盐酸盐

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About This Item

经验公式(希尔记法):
C6H13NO5 · HCl
CAS号:
分子量:
215.63
Beilstein:
3697825
EC號碼:
MDL號碼:
分類程式碼代碼:
12352209
PubChem物質ID:
NACRES:
NA.75

生物源

fish cartilage (shark)

產品線

BioReagent

化驗

≥99%

技術

cell culture | mammalian: suitable

雜質

Glucosamine, essentially free

溶解度

water: 50 mg/mL, clear to very slightly hazy, colorless to very faintly yellow

運輸包裝

ambient

儲存溫度

room temp

SMILES 字串

Cl.N[C@@H](C=O)[C@@H](O)[C@@H](O)[C@H](O)CO

InChI

1S/C6H13NO5.ClH/c7-3(1-8)5(11)6(12)4(10)2-9;/h1,3-6,9-12H,2,7H2;1H/t3-,4+,5+,6-;/m0./s1

InChI 密鑰

CBOJBBMQJBVCMW-NQZVPSPJSA-N

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應用

使用D-(+)-半乳糖胺盐:
  • 诱导小鼠肝损伤
  • 炎症性肝损伤
  • 急性肝衰竭(ALF)

生化/生理作用

半乳糖胺(D-GalN)由半乳糖合成,是一种潜在的肝毒剂。D-GalN与脂多糖结合可导致致命性肝损伤和肝衰竭的恶化。它使细胞对细胞因子,特别是肿瘤坏死因子(TNF)的毒性作用变得敏感。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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GABA, gamma-Aminobutyric Acid, Protects Against Severe Liver Injury
Hata T, et al.
The Journal of Surgical Research, 236, 172-183 (2019)
Yao Wang et al.
Journal of inflammation research, 14, 1473-1485 (2021-04-23)
The glycolysis pathway of M1 macrophages is a key factor affecting the inflammatory response. The aim of this article is to investigate the role of histone deacetylase 6 (HDAC6) in the M1 macrophage glycolysis pathway during acute liver failure (ALF).
Marina S Drutskaya et al.
Journal of leukocyte biology, 107(6), 933-939 (2020-02-11)
Systemic TNF neutralization can be used as a therapy for several autoimmune diseases. To evaluate the effects of cell type-restricted TNF blockade, we previously generated bispecific antibodies that can limit TNF secretion by myeloid cells (myeloid cell-specific TNF inhibitors or
Catalpol protects mice against Lipopolysaccharide/D-galactosamine-induced acute liver injury through inhibiting inflammatory and oxidative response
Zhang H, et al.
Testing, 9(3), 3887-3887 (2018)
D-galactosamine lethality model: scope and limitations
Silverstein R
Journal of endotoxin research, 10(3), 147-162 (2004)

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