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F7932

Sigma-Aldrich

泛昔洛韦

≥98% (HPLC)

别名:

2-[2-(2-氨基-9H-嘌呤-9-基)乙基]-1,3-丙二醇二乙酸酯, BRL 42810

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About This Item

经验公式（希尔记法）:
C14H19N5O4
CAS号:
104227-87-4
分子量:
321.33
MDL號碼:
MFCD00866964
分類程式碼代碼:
12352200
PubChem物質ID:
329799767
NACRES:
NA.77

化驗

≥98% (HPLC)

形狀

solid

儲存條件

desiccated

溶解度

DMSO: ≥10 mg/mL

起源

Novartis

儲存溫度

2-8°C

SMILES 字串

CC(=O)OCC(CCn1cnc2cnc(N)nc12)COC(C)=O

InChI

1S/C14H19N5O4/c1-9(20)22-6-11(7-23-10(2)21)3-4-19-8-17-12-5-16-14(15)18-13(12)19/h5,8,11H,3-4,6-7H2,1-2H3,(H2,15,16,18)

InChI 密鑰

GGXKWVWZWMLJEH-UHFFFAOYSA-N

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應用

泛昔洛韦用于疱疹病毒感染和乙肝药物开发研究。它可用作参考化合物。泛昔洛韦可用于研究控制转化为喷昔洛韦和其他代谢物的因素。

生化／生理作用

泛昔洛韦是一种抗逆转录病毒鸟苷类似物，用于治疗疱疹病毒感染和乙肝。泛昔洛韦可迅速转化为喷昔洛韦。病毒胸苷激酶将喷昔洛韦磷酸化为单磷酸形式，然后细胞激酶又将其转换为三磷酸喷昔洛韦。喷昔洛韦三磷酸可竞争性抑制病毒 DNA 聚合酶，从而抑制病毒复制。长时间服用会形成耐药性；这通常表现为筛选出了一批 DNA 聚合酶基因逆转录酶结构域突变的预先存在的耐药性菌株。

特點和優勢

该化合物由 Novartis 开发。想要浏览其他由制药公司开发的化合物以及已批准药物/候选药物清单，请单击此处。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

分析证书(COA)

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