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一般說明
6-脱氧-D-葡萄糖是D-葡萄糖(右旋葡萄糖)的一种结构同源物和稳定的类似物。它在碳6位上缺少羟基。它也是甘露糖的类似物。
應用
6-脱氧-D-葡萄糖已被用作圆二色性测量中的标准品。它也作为糖用于孵育经饥饿处理的双歧杆菌HMX44A.atg1-1细胞,从而用于显微镜研究。
生化/生理作用
2-脱氧-D-葡萄糖(2-DG)在研究葡萄糖的生物学功能中可用作糖酵解抑制剂。它不可被代谢,会引发内质网的应激,因而可阻止癌细胞中碳水化合物的代谢。它具有靶向抗化学性缺氧癌细胞的治疗潜力。2-DG可通过取代甘露糖终止 N-连接糖基化。
儲存類別代碼
11 - Combustible Solids
水污染物質分類(WGK)
WGK 3
閃點(°F)
Not applicable
閃點(°C)
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
其他客户在看
Proceedings of the National Academy of Sciences of the United States of America, 88(13), 5724-5728 (1991-07-01)
Nutrients play a critical role in the decision to initiate a new cell cycle. Addition of nutrients to arrested cells such as stationary-phase cells and spores induces them to begin growth. We have analyzed the nutrients required to induce early
Journal of the American Chemical Society, 133(19), 7292-7295 (2011-04-26)
DesII, a radical S-adenosyl-l-methionine (SAM) enzyme from Streptomyces venezuelae, catalyzes the deamination of TDP-4-amino-4,6-dideoxy-D-glucose to TDP-3-keto-4,6-dideoxy-D-glucose in the desosamine biosynthetic pathway. DesII can also catalyze the dehydrogenation of TDP-D-quinovose to the corresponding 3-keto sugar. Similar to other radical SAM enzymes
Proceedings of the National Academy of Sciences of the United States of America, 105(46), 17807-17811 (2008-11-14)
The glucose analogue 2-deoxy-D-glucose (2-DG) restrains growth of normal and malignant cells, prolongs the lifespan of C. elegans, and is widely used as a glycolytic inhibitor to study metabolic activity with regard to cancer, neurodegeneration, calorie restriction, and aging. Here
Molecular and biochemical parasitology, 60(1), 9-18 (1993-07-01)
Kinetic parameters for entry of D-fructose into Trypanosoma brucei brucei have been determined. The net uptake of D-fructose was found to be rapid and occurred at a rate which was comparable with that observed for uptake of D-glucose. The Km
The Journal of protozoology, 39(5), 613-618 (1992-09-01)
Leishmania donovani promastigotes were grown to late log phase, washed and resuspended in iso-osmotic buffer containing L-arginine, and the rate of urea formation was then measured under various conditions. Addition of glucose or mannose activated urea formation, whereas 2-deoxyglucose inhibited
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