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About This Item
经验公式（希尔记法）:
C15H10O4 · xH2O
CAS号:
分子量:
254.24 (anhydrous basis)
EC 号:
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
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应用
7,8-二羟基黄酮水合物已被用作小鼠中原肌球蛋白受体激酶（TrkB）激动剂，并用于抑制TrkB以监控诱发性兴奋性突触后电流 (eEPSC) 。
生化/生理作用
7,8-二羟基黄酮是一种选择性TrkB受体激动剂
7,8-二羟基黄酮是一种选择性酪氨酸激酶受体B（TrkB）受体激动剂。它表现出了脑源性神经营养因子（BDNF）的所有治疗效果，如保护神经元免于凋亡、抑制红藻氨酸诱导的毒性、减少中风中的梗塞体积以及在帕金森病动物模型中的神经保护—没有BDNF限制了其治疗潜力的较差药代动力学特征。
7,8-二羟基黄酮（7,8-DHF），可用于帮助识别和区分由TrkB激活介导的生理效应和细胞信号传导通路，例如那些涉及的神经保护、记忆、血管舒张和高血压。7,8-二羟基黄酮会引发对东莨菪碱所致阿尔茨海默样病变的保护作用。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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