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About This Item
经验公式（希尔记法）:
C10H16N5O12P3
CAS号:
分子量:
491.18
MDL號碼:
分類程式碼代碼:
41106305
PubChem物質ID:
NACRES:
NA.51
推荐产品
化驗
≥95%
形狀
powder
分子量
491.18 g/mol
儲存溫度
−20°C
SMILES 字串
[Na].Nc1ncnc2n(cnc12)C3OC(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)CC3O
InChI
1S/C10H16N5O12P3.Na.H/c11-8-7-9(13-3-12-8)15(4-14-7)10-6(16)1-5(25-10)2-24-29(20,21)27-30(22,23)26-28(17,18)19;;/h3-6,10,16H,1-2H2,(H,20,21)(H,22,23)(H2,11,12,13)(H2,17,18,19);;
InChI 密鑰
FRGBONDYLMUOMH-UHFFFAOYSA-N
相关类别
一般說明
虫草素（Cordycepin，3′-脱氧腺苷）是从蛹虫草Cordyceps militaris中提取的细胞毒性腺苷类似物和生物活性试剂。5′-三磷酸虫草素是虫草素的毒性衍生物。
應用
5′-三磷酸虫草素钠盐已用于：
- 作为RNA降解检测的转录抑制剂
- 在收获前抑制HEK293T细胞的多腺苷化，通过免疫共沉淀(co-Ips)法进行体外相互作用研究
- 作为聚合酶抑制的体外检测实验中的阳性对照
- 作为生产虫草素单磷酸的前体
生化／生理作用
虫草素可激活人类AMP活化蛋白激酶(AMPK)，发挥多种代谢功能。三磷酸虫草素通过体外阻断[3H]GMP掺入来抑制微小核糖核酸病毒(picornavirus)聚合酶特异性RNA合成。它也可抑制RNA合成而延缓细胞生长。
虫草素 5′-三磷酸盐通过 poly (A) 聚合酶掺入核酸中。因为它缺少一个 3′-羟基链的产生，它可用于 3′-RNA 的末端标记。
訊號詞
Warning
危險分類
Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
標靶器官
Respiratory system
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
個人防護裝備
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
其他客户在看
Junhua Pan et al.
Nature, 577(7789), 275-279 (2019-11-08)
Respiratory syncytial virus (RSV) and human metapneumovirus (HMPV) cause severe respiratory diseases in infants and elderly adults1. No vaccine or effective antiviral therapy currently exists to control RSV or HMPV infections. During viral genome replication and transcription, the tetrameric phosphoprotein
G Costanzo et al.
Molecular and cellular biology, 21(9), 3166-3178 (2001-04-05)
Quantitative analysis of multiple-hit potassium permanganate (KMnO(4)) footprinting has been carried out in vivo on Saccharomyces cerevisiae 5S rRNA genes. The results fix the number of open complexes at steady state in exponentially growing cells at between 8 and 17%
Lisa S Chen et al.
British journal of haematology, 140(6), 682-391 (2008-01-22)
Multiple myeloma (MM) is an incurable plasma cell malignancy that is slow-growing, and thus traditional DNA-replication directed chemotherapeutics are ineffective. We hypothesized that those agents that target RNA-directed processes would be successful in MM. To test this postulate, cordycepin, a
3′-end labeling of RNA with recombinant yeast poly(A) polymerase.
Lingner J, Keller W.
Nucleic Acids Research, 25, 2917-2920 (1993)
D L Panicali et al.
Journal of virology, 25(1), 124-128 (1978-01-01)
Cordycepin triphosphate inhibited in vitro [3H]GMP incorporation by pricornavirus-specific polymerase complexes isolated from infected HeLa cells. The inhibition of [3H]GMP incorporation could be reversed with ATP added to the reaction mixture along with the inhibitor, but not with GTP so
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