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C5235

Sigma-Aldrich

细胞色素P450 人

4F3B isozyme microsomes, with P450 Reductase and cytochrome b5, recombinant, expressed in baculovirus infected insect cells (BTI-TN-5B1-4)

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About This Item

EC 号:
1.6.2.4 (BRENDA, IUBMB)
MDL號碼:
MFCD03456520
分類程式碼代碼:
12161501
NACRES:
NA.47

生物源

human

品質等級

200

重組細胞

expressed in baculovirus infected insect cells (BTI-TN-5B1-4)

形狀

solution

分子量

45-60 kDa

包裝

vial of 0.5 nmol

UniProt登錄號

Q08477

應用

cell analysis

運輸包裝

dry ice

儲存溫度

−70°C

基因資訊

human ... CYP4F3(4051)

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生化／生理作用

细胞色素 P450 是一个具有异质性的同工酶家族，其主要功能是氧化小分子，既是中间代谢（如脂肪酸）的功能，也是对外源化合物（药物或毒素）解毒的功能。一些亚型具有较窄的底物特异性，而另一些则是替代的。
The CYP4F3B isoform catalyzes the 20-hydroxylation of leukotriene B4.

單位定義

One unit will reduce 1 nanomole of cytochrome C per minute at pH 7.4 at 37 deg C.

外觀

Solution in 100 mM potassium phosphate buffer, pH 7.4.

儲存類別代碼

12 - Non Combustible Liquids

水污染物質分類（WGK）

WGK 2

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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P Christmas et al.
The Journal of biological chemistry, 274(30), 21191-21199 (1999-07-20)
Cytochrome P450 4F3 (CYP4F3) catalyzes the inactivation of leukotriene B(4) by omega-oxidation in human neutrophils. To understand the regulation of CYP4F3 expression, we analyzed the CYP4F3 gene and cloned a novel isoform (CYP4F3B) that is expressed in fetal and adult
Xiangrong Zhang et al.
PloS one, 9(4), e94962-e94962 (2014-04-17)
The present study characterized in vitro metabolites of 20(R)-25-methoxyl-dammarane-3β, 12β, 20-triol (20(R)-25-OCH3-PPD) in mouse, rat, dog, monkey and human liver microsomes. 20(R)-25-OCH3-PPD was incubated with liver microsomes in the presence of NADPH. The reaction mixtures and the metabolites were identified
Dongju Lin et al.
Drug metabolism and disposition: the biological fate of chemicals, 42(10), 1727-1736 (2014-07-16)
Diosbulbin B (DIOB), a furan-containing diterpenoid lactone, is the most abundant component of Dioscorea bulbifera L. (DB), a traditional Chinese medicine herb. Administration of purified DIOB or DB extracts has been reported to cause liver injury in animals. The mechanisms
Mirza Bojić et al.
Drug metabolism and disposition: the biological fate of chemicals, 42(9), 1438-1446 (2014-07-06)
Cilengitide is a stable cyclic pentapeptide containing an Arg-Gly-Asp motif responsible for selective binding to αVβ3 and αVβ5 integrins. The candidate drug showed unexpected inhibition of cytochrome P450 (P450) 3A4 at high concentrations, that is, a 15-mM concentration caused attenuation

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