推荐产品
生物源
human
品質等級
重組細胞
expressed in baculovirus infected insect cells (BTI-TN-5B1-4)
形狀
solution
分子量
45-60 kDa
包裝
vial of 0.5 nmol
適合性
suitable for molecular biology
UniProt登錄號
應用
cell analysis
運輸包裝
dry ice
儲存溫度
−70°C
基因資訊
human ... CYP1B1(1545)
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一般說明
Research Area: Immuno and CKS
Cytochromes are a type of protein belonging to superfamilies containing heme as a cofactor, making them hemoproteins. These proteins, also known as CYPs, serve as substrates in enzymatic reactions. The term "P450" originates from the enzyme′s maximum optical density peak at 450 nm when in its reduced state combined with carbon monoxide. Cytochromes are present in various tissues throughout the human body, with a predominant presence in intestinal and hepatic tissues.
Cytochromes are a type of protein belonging to superfamilies containing heme as a cofactor, making them hemoproteins. These proteins, also known as CYPs, serve as substrates in enzymatic reactions. The term "P450" originates from the enzyme′s maximum optical density peak at 450 nm when in its reduced state combined with carbon monoxide. Cytochromes are present in various tissues throughout the human body, with a predominant presence in intestinal and hepatic tissues.
應用
Cytochrome P450 human has been used in aflatoxin B1 (AFB1) metabolites analysis to study its effects on AFB1-induced cytotoxicity and micronuclei formation in human hepatocyte (L-02) and human lymphoblastoid (TK6) cells. It has also been used in cell-free cytochrome P4501B1 (CYP1B1) inhibition assays.
生化／生理作用
Cytochromes play a crucial role in metabolizing a wide range of xenobiotic compounds and are engaged in diverse functions such as steroid metabolism, deactivation of drugs and procarcinogens, metabolism of fatty acids, detoxification of xenobiotic substances, and breakdown of exogenous compounds. It facilitates the oxidation of substances using iron. CYP is well-established that changes in CYP enzymes often occur as a common consequence of immune system activation following infection and inflammation. Despite the overlapping effects of cytokines, the activity of human P450s is independently regulated in infection and inflammation.
细胞色素 P450 是一个具有异质性的同工酶家族，其主要功能是氧化小分子，既是中间代谢（如脂肪酸）的功能，也是对外源化合物（药物或毒素）解毒的功能。一些亚型具有较窄的底物特异性，而另一些则是替代的。
單位定義
One unit will reduce 1 nanomole of cytochrome C per minute at pH 7.4 at 37 deg C.
外觀
Solution in 100 mM potassium phosphate buffer, pH 7.4.
準備報告
Microsomes containing human CYP1B1 and recombinant human NADPH-P450 reductase.
分析報告
Tested for the ability to catalyze the 7-deethylation of ethoxyresorufin.
儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
其他客户在看
Cytochrome P450 structure, function and clinical significance: a review
Manikandan P and Nagini S
Current Drug Targets, 19(1), 38-54 (2018)
Human CYP1B1 enzyme-mediated, AhR enhanced activation of aflatoxin B1 for its genotoxicity in human cells
Chen Y, et al.
Toxicology Letters, 373, 132-140 (2023)
The role of cytochromes P450 in infection
Stavropoulou E, et al.
Frontiers in Immunology, 9, 314116-314116 (2018)
D P Bofinger et al.
Toxicological sciences : an official journal of the Society of Toxicology, 62(2), 299-314 (2001-07-14)
Endometriosis is a debilitating disease estimated to affect 10% of reproductive-age women and characterized by the growth of endometrial tissue outside of the uterus. The present study characterizes a human endometrial explant culture model for studying the direct effects of
Sarah J Phelan-Dickinson et al.
Toxicological sciences : an official journal of the Society of Toxicology, 177(1), 188-201 (2020-07-01)
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