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Merck

C221

Sigma-Aldrich

羧基-PTIO 钾盐

别名:

2-(4-羧基苯基)-4,4,5,5-四甲基咪唑啉-1-氧基-3-氧化物 钾盐, 2-(4-羧基苯基)-4,5-二氢-4,4,5,5-四甲基-1H-咪唑-1-基氧基-3-氧化物 钾盐

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About This Item

经验公式(希尔记法):
C14H16KN2O4
分子量:
315.39
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.32

生物源

synthetic (organic)

化驗

≥98% (TLC)

形狀

powder

mp

>270 °C

溶解度

H2O: 100 mg/mL
DMSO: soluble (lit.)(lit.)
methanol: soluble (lit.)(lit.)

儲存溫度

2-8°C

SMILES 字串

[K+].CC1(C)N([O])C(c2ccc(cc2)C([O-])=O)=[N+]([O-])C1(C)C

InChI

1S/C14H17N2O4.K/c1-13(2)14(3,4)16(20)11(15(13)19)9-5-7-10(8-6-9)12(17)18;/h5-8H,1-4H3,(H,17,18);/q;+1/p-1

InChI 密鑰

VYEUQMVIGXFZQU-UHFFFAOYSA-M

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一般說明

2-(4-羧苯基)-4,4,5,5-四甲基咪唑啉-1-氧基-3-氧化物(羧基-PTIO)主要被认为是一氧化氮(NO)清除剂。

應用

羧基-PTIO钾盐通过检查反应混合物中羟基自由基或硝酸的生成情况,确定反应混合物中一氧化氮的生成情况。还可添加至神经元,分析其对葡萄糖/氧气/血清剥夺(GOSD)状态的影响(4)

生化/生理作用

其与一氧化氮反应可形成羧基-PTI衍生物,产物可进一步抑制一氧化氮合成酶的活性。
羧基-PTIO可以与一氧化氮(NO)快速反应生成二氧化氮(NO2)。 可用于预防 体内脂多糖刺激引起的低血压和内毒素性休克。羧基-PTIO还可以阻断 体外 NO刺激造成的血管松弛。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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Anton Misak et al.
Molecules (Basel, Switzerland), 24(6) (2019-03-27)
Doxycycline (DOXY) is an antibiotic routinely prescribed in human and veterinary medicine for antibacterial treatment, but it has also numerous side effects that include oxidative stress, inflammation, cancer or hypoxia-induced injury. Endogenously produced hydrogen sulfide (H₂S) and polysulfides affect similar
Megumi Hada et al.
International journal of molecular sciences, 20(18) (2019-09-07)
Previously, we investigated the dose response for chromosomal aberration (CA) for exposures corresponding to less than one particle traversal per cell nucleus by high energy and charge (HZE) particles, and showed that the dose responses for simple exchanges for human
Nitric oxide scavenger carboxy-PTIO potentiates the inhibition of dopamine uptake by nitric oxide donors
Cao B J and Reith M EA
European Journal of Pharmacology, 448(1), 27-30 (2002)
Raymond N Allan et al.
Nitric oxide : biology and chemistry, 65, 43-49 (2017-02-27)
Bacterial biofilms show high tolerance towards antibiotics and are a significant problem in clinical settings where they are a primary cause of chronic infections. Novel therapeutic strategies are needed to improve anti-biofilm efficacy and support reduction in antibiotic use. Treatment
Interference of carboxy-PTIO with nitric oxide-and peroxynitrite-mediated reactions
Pfeiffer S, et al.
Free Radical Biology & Medicine, 22(5), 787-794 (1997)

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