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B7431

Sigma-Aldrich

苔藓抑素1

≥99%, solid

别名:

NSC 339555

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About This Item

经验公式（希尔记法）:
C47H68O17
CAS号:
83314-01-6
分子量:
905.03
MDL號碼:
MFCD00893832
分類程式碼代碼:
12352200
PubChem物質ID:
24891991
NACRES:
NA.77

品質等級

100

化驗

≥99%

形狀

solid

顏色

white

溶解度

DMSO: soluble
ethanol: soluble

儲存溫度

−20°C

SMILES 字串

[H]\C(C(=O)OC)=C1/C[C@@]2([H])C[C@]3(O)O[C@]([H])(C[C@@H](O)CC(=O)O[C@H](C[C@]4([H])C\C(=C(\[H])C(=O)OC)[C@H](OC(=O)\C=C\C=C\CCC)[C@@](O)(O4)C(C)(C)\C=C\[C@@]([H])(C1)O2)[C@@H](C)O)C[C@H](OC(C)=O)C3(C)C

InChI

1S/C47H68O17/c1-10-11-12-13-14-15-39(51)62-43-31(22-41(53)58-9)21-34-25-37(28(2)48)61-42(54)24-32(50)23-35-26-38(59-29(3)49)45(6,7)46(55,63-35)27-36-19-30(20-40(52)57-8)18-33(60-36)16-17-44(4,5)47(43,56)64-34/h12-17,20,22,28,32-38,43,48,50,55-56H,10-11,18-19,21,23-27H2,1-9H3/b13-12+,15-14+,17-16+,30-20+,31-22+/t28-,32-,33+,34+,35-,36+,37-,38+,43+,46+,47-/m1/s1

InChI 密鑰

MJQUEDHRCUIRLF-TVIXENOKSA-N

應用

苔藓虫素1已用于研究其对小鼠结肠炎等自发性克罗恩病′（CD）的影响。它也已用于研究其作为驱虫药对大鼠中成年鼠管线虫感染的影响。

生化／生理作用

苔藓虫素(Bry1)是一种大环内酯。这种突触发生性化合物是从海洋苔藓虫多室草苔虫中获得的。Bry1能够逆转突触损失。它可以促进多种神经系统疾病动物模型中的突触成熟。当用于脑室给药时，它具有抗抑郁活性。现已确知Bry1参与保护细胞紧密连接（TJ）、抗炎功能和免疫调节。
从海洋苔藓虫 Bugula neritina 中分离的大环内酯可首先激活并随后下调蛋白激酶C（PKC）。其转移PKCδ 和ε的效果比佛波醇肉豆蔻酸乙酸酯更好。

其他說明

与水溶液中的玻璃和塑料结合

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

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N Kedei et al.
Biochemical pharmacology, 85(3), 313-324 (2012-11-14)
Bryostatin 1, like the phorbol esters, binds to and activates protein kinase C (PKC) but paradoxically antagonizes many but not all phorbol ester responses. Previously, we have compared patterns of biological response to bryostatin 1, phorbol ester, and the bryostatin
Dan Zhao et al.
Cellular immunology, 271(2), 392-400 (2011-09-10)
The majority of melanoma cells express detectable levels of HLA class II proteins, and an increased threshold of cell surface class II is crucial for the stimulation of CD4+ T cells. Bryostatin-1, a protein kinase C (PKC) activator, has been
Yasuyuki Ogawa et al.
The Journal of organic chemistry, 78(1), 104-115 (2012-11-06)
The Prins cyclization of syn-β-hydroxy allylsilanes and aldehydes gives cis-2,6-disubstituted 4-alkylidenetetrahydropyrans as sole products in excellent yields regardless of the aldehyde (R″) or syn-β-hydroxy allylsilane substituent (R') used. By reversing the R″ and R' groups, complementary exocyclic stereocontrol can be
Maciej Kmieciak et al.
Journal of visualized experiments : JoVE, (47)(47), doi:10-doi:10 (2011-02-10)
It was reported that breast cancer patients have pre-existing immune responses against their tumors(1,2). However, such immune responses fail to provide complete protection against the development or recurrence of breast cancer. To overcome this problem by increasing the frequency of
Maria Eugenia Ariza et al.
The Journal of biological chemistry, 286(1), 24-34 (2010-11-03)
Bryostatin-1 (Bryo-1), a natural macrocyclic lactone, is clinically used as an anti-cancer agent. In this study, we demonstrate for the first time that Bryo-1 acts as a Toll-like receptor 4 (TLR4) ligand. Interestingly, activation of bone marrow-derived dendritic cells (in
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