B5188

Butenafine hydrochloride

≥98% (HPLC)

• 别名: Butenafine hydrochloride, Mentax, N-(p-tert-butylbenzyl)-N-methyl-1-naphthalenemethylamine hydrochloride, N-[[4-(1,1-Dimethylethyl)phenyl]methyl]-N-methyl-1-naphthalenemethanamine hydrochloride
• 经验公式（希尔记法）: C₂₃H₂₇N · HCl
• CAS号: 101827-46-7
• 分子量: 353.93
• MDL號碼: MFCD00917064
• 分類程式碼代碼: 51111800
• PubChem物質ID: 329773252
• NACRES: NA.77

属性

• 化驗: ≥98% (HPLC)
• 形狀: powder
• 儲存條件: desiccated
• 顏色: white to off-white
• 溶解度: DMSO: ≥10 mg/mL
• 起源: Schering Plough
• 儲存溫度: room temp
• SMILES 字串: Cl.CN(Cc1ccc(cc1)C(C)(C)C)Cc2cccc3ccccc23
• InChI: 1S/C23H27N.ClH/c1-23(2,3)21-14-12-18(13-15-21)16-24(4)17-20-10-7-9-19-8-5-6-11-22(19)20;/h5-15H,16-17H2,1-4H3;1H
• InChI 密鑰: LJBSAUIFGPSHCN-UHFFFAOYSA-N

说明

一般說明

Butenafine hydrochloride is chemically known as N-4-tertbutylbenzyl-N-methyl-1-naphthalenemethylamine hydrochloride. Butenafine, a benzylamine derivative, is a new generation antimycotic compound. It is easily soluble in methanol, ethanol, dichloromethane, and chloroform, but not in water. The allyl radical in butenafine hydrochloride is substituted by a butylbenzyl group.

應用

Butenafine hydrochloride has been used as a standard in high-performance liquid chromatography (HPLC) method to determine butenafine hydrochloride in butenafine-loaded nanosponges.

生化／生理作用

Butenafine exhibits fungicidal and antimycotic activity. This fungal squalene epoxidase inhibitor serves as an effective fungicide against T. rubrum, T. mentagrophytes, Microsporum canis, Aspergillus fumigatus, Sporothrix schenckii, Candida parapsilosis, and C. albicans. It is considered more effective and rapid than other antifungal drugs at curing dermatophytosis and preventing recurrences. In humans, it is used topically to treat tinea conditions and superficial candidiasis. Butenafine is considered a promising antimycotic compound to treat tinea pedis due to its efficiency, safety profile, relapse rates, and cost-effectiveness.

Butenafine possesses antifungal property. It is a squalene epoxidase inhibitor. Butenafine can inhibit the synthesis of ergosterol needed in fungal cell membranes.

特點和優勢

This compound was developed by Schering Plough. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

安全信息

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H312
• 防範說明: P280 - P302 + P352 + P312 - P362 + P364 - P501
• 危險分類: Acute Tox. 4 Dermal
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: nwg
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable