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Merck

B175

Sigma-Aldrich

BW 723C86

≥98% (HPLC)

别名:

α-methyl-5-(2-thienylmethoxy)-1H-Indole-3-ethanamine monohydrochloride

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About This Item

经验公式(希尔记法):
C16H18N2OS · HCl
分子量:
322.85
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

化驗

≥98% (HPLC)

形狀

powder

顏色

white to beige

溶解度

H2O: 1 mg/mL, clear

SMILES 字串

Cl.CC(N)Cc1c[nH]c2ccc(OCc3cccs3)cc12

InChI

1S/C16H18N2OS.ClH/c1-11(17)7-12-9-18-16-5-4-13(8-15(12)16)19-10-14-3-2-6-20-14;/h2-6,8-9,11,18H,7,10,17H2,1H3;1H

InChI 密鑰

PYJBJMIBANAOFJ-UHFFFAOYSA-N

基因資訊

human ... HTR2B(3357)

生化/生理作用

5-HT2B serotonin receptor agonist.

注意

Hygroscopic; photosensitive

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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G A Kennett et al.
Neuropharmacology, 36(2), 233-239 (1997-02-01)
The 5-HT2B receptor agonist, BW 723C86 (10 and 20 mg/kg s.c.), increased the time spent in feeding behaviour of freely-fed rats in observation cages over 15 min. BW 723C86 (20 and 50 mg/kg s.c. 30 min pre-test) also modestly increased
G A Kennett et al.
British journal of pharmacology, 117(7), 1443-1448 (1996-04-01)
1. BW 723C86 (3 and 10 mg kg-1, s.c. 30 min pretest), a 5-HT2B receptor agonist, increased total interaction, but not locomotion in a rat social interaction test, a profile consistent with anxiolysis. 2. The effect of BW 723C86 in
Raphael R Perim et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 314(5), R709-R715 (2018-02-01)
Intermittent spinal serotonin receptor activation elicits phrenic motor facilitation (pMF), a form of spinal respiratory motor plasticity. Episodic activation of either serotonin type 2 (5-HT2) or type 7 (5-HT7) receptors elicits pMF, although they do so via distinct cellular mechanisms
Yasmine Chabbi-Achengli et al.
The American journal of pathology, 186(4), 927-937 (2016-03-13)
Rheumatoid arthritis is a chronic disease that results in a disabling and painful condition as it progresses to destruction of the articular cartilage and ankylosis of the joints. Although the cause of the disease is still unknown, evidence argues that
Marcus Niebert et al.
PloS one, 6(7), e21395-e21395 (2011-07-27)
Neurons of the respiratory network in the lower brainstem express a variety of serotonin receptors (5-HTRs) that act primarily through adenylyl cyclase. However, there is one receptor family including 5-HT(2A), 5-HT(2B), and 5-HT(2C) receptors that are directed towards protein kinase

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