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Merck

R0200000

利血平

European Pharmacopoeia (EP) Reference Standard

别名:

(3β, 16β, 17α, 18β, 20α)-11,17-二甲氧基-18-[(3,4,5-三甲氧基苯甲酰基)氧基]育亨烷-16-羧酸甲酯

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About This Item

经验公式(希尔记法):
C33H40N2O9
CAS号:
分子量:
608.68
Beilstein:
102014
MDL號碼:
分類程式碼代碼:
41116107
PubChem物質ID:
NACRES:
NA.24

等級

pharmaceutical primary standard

API 家族

reserpine

製造商/商標名

EDQM

mp

~265 °C (dec.)

應用

pharmaceutical (small molecule)

格式

neat

儲存溫度

2-8°C

SMILES 字串

CO[C@H]1[C@@H](C[C@@H]2CN3CCc4c([nH]c5cc(OC)ccc45)[C@H]3C[C@@H]2[C@@H]1C(=O)OC)OC(=O)c6cc(OC)c(OC)c(OC)c6

InChI

1S/C33H40N2O9/c1-38-19-7-8-20-21-9-10-35-16-18-13-27(44-32(36)17-11-25(39-2)30(41-4)26(12-17)40-3)31(42-5)28(33(37)43-6)22(18)15-24(35)29(21)34-23(20)14-19/h7-8,11-12,14,18,22,24,27-28,31,34H,9-10,13,15-16H2,1-6H3/t18-,22+,24-,27-,28+,31+/m1/s1

InChI 密鑰

QEVHRUUCFGRFIF-MDEJGZGSSA-N

基因資訊

human ... SLC18A2(6571)

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一般說明

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

應用

Reserpine EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

生化/生理作用

抑制儿茶酚胺和血清素的囊泡摄取。

包裝

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他說明

Sales restrictions may apply.

相關產品

象形圖

Health hazardExclamation mark

訊號詞

Danger

危險分類

Acute Tox. 4 Oral - Carc. 2 - Repr. 1A - STOT SE 3

標靶器官

Central nervous system

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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分析证书(COA)

Lot/Batch Number

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Sandy D Shamon et al.
The Cochrane database of systematic reviews, (4)(4), CD007655-CD007655 (2009-10-13)
Many antihypertensive agents exist today for the treatment of primary hypertension (systolic blood pressure >/=140 mmHg and/or diastolic blood pressure >/=90 mmHg). Randomised controlled trials have been carried out to investigate the evidence for these agents.There is, for example, strong
How reserpine and chlorpromazine act: the impact of key discoveries on the history of psychopharmacology.
G Curzon
Trends in pharmacological sciences, 11(2), 61-63 (1990-02-01)
R E Stitzel
Pharmacological reviews, 28(3), 179-208 (1976-09-01)
Orally administered reserpine is readily absorbed from the GI tract. During this process at least a portion of the drug is metabolized by the intestinal mucosa and then presumably is acted upon by serum esterases. Methylreserpate and trimethoxybenzoic acid are
Reserpine-induced supersensitivity to the cardiac effects of agonists.
K D Meisheri et al.
Life sciences, 24(6), 473-480 (1979-02-05)
Reserpine: a challenge for total synthesis of natural products.
Fen-Er Chen et al.
Chemical reviews, 105(12), 4671-4706 (2005-12-15)

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