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等級
pharmaceutical primary standard
API 家族
benzarone
製造商／商標名
EDQM
應用
pharmaceutical (small molecule)
格式
neat
儲存溫度
2-8°C
InChI
1S/C17H14O3/c1-2-14-16(13-5-3-4-6-15(13)20-14)17(19)11-7-9-12(18)10-8-11/h3-10,18H,2H2,1H3
InChI 密鑰
RFRXIWQYSOIBDI-UHFFFAOYSA-N
一般說明
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
應用
Benzarone EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.
包裝
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
其他說明
Sales restrictions may apply.
W Voelter et al.
Journal of chromatography, 290, 1-12 (1984-05-04)
Using 2-ethyl-3-(4- hydroxybenzoyl )benzofuran ( EHBB ) as an example, biotransformation in rabbits and rats and by rat hepatocyte suspensions was studied by high-performance liquid chromatography (HPLC) and mass spectrometry. The biotransformation of N-alkyl-substituted piperidines by rat hepatocytes gives valuable
[On the site of action of benzarone and some other agents influencing the intracellular concentration of cyclic nucleotides].
L O Zwillenberg et al.
Arzneimittel-Forschung, 32(9), 1114-1120 (1982-01-01)
Subfulminant hepatitis requiring liver transplantation after benzarone administration.
M Gehenot et al.
Journal of hepatology, 20(6), 842-842 (1994-06-01)
H Iven et al.
Cancer chemotherapy and pharmacology, 21(4), 337-342 (1988-01-01)
In anesthetized rabbits, continuous infusion of methotrexate (MTX; 30 micrograms kg-1 min-1) established steady-state plasma concentrations for MTX and the metabolite 7-hydroxymethotrexate (7-OH-MTX) within 40 min. Fifty percent of the infused dose was eliminated unchanged by the kidneys and the
S G Wood et al.
Xenobiotica; the fate of foreign compounds in biological systems, 17(7), 881-896 (1987-07-01)
1. The metabolic fate of 14C-benzarone in the rat and dog has been compared to that in human subjects. An oral dose was well-absorbed in all three species. However, the 14C excretion patterns differed: humans (100 mg) excreted means of
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