8.22278

Acetic anhydride

for synthesis

• 别名: Acetic anhydride, Acetyl acetate, Acetyl oxide
• 线性分子式: (CH₃CO)₂O
• CAS号: 108-24-7
• 分子量: 102.09
• MDL號碼: MFCD00008705
• 分類程式碼代碼: 12352106
• 酶委員會索引編號: 203-564-8
• NACRES: NA.22

属性

• 蒸汽壓力: 4 hPa ( 20 °C)
• 品質等級: 200
• 化驗: ≥98.0% (GC)
• 形狀: liquid
• 自燃溫度: 330 °C
• 效力: 630 mg/kg LD₅₀, oral (Rat); 4320 mg/kg LD₅₀, skin (Rabbit)
• expl. lim.: 2.0-10.2 % (v/v)
• pH值: 3 (20 °C, 10 g/L in H₂O)
• mp: -73 °C
• 轉變溫度: flash point 49 °C
• 密度: 1.08 g/cm³ at 20 °C
• 儲存溫度: 2-30°C
• InChI: 1S/C4H6O3/c1-3(5)7-4(2)6/h1-2H3
• InChI 密鑰: WFDIJRYMOXRFFG-UHFFFAOYSA-N

说明

一般說明

Acetic anhydride is a widely used reagent in organic synthesis. The reagent is effective for acetylating alcohols, amines, and thiols. Additionally, it is used in various named reactions such as the Pummerer reaction, the Perkin reaction, the Polonovski reaction, the N-oxide reaction, and the Thiele reaction. Acetic anhydride is an effective reagent during oxidation of alcohols, dehydration, ether cleavage, enol acetate formation, and gem-diacetate formation.

應用

Acetic anhydride is used:

• In the solvent free acylation of 2-methylfuran to 2-acetyl-5-methylfuran in presence of hydroxide fluorides catalyst.
• As a catalyst in the synthesis of 3-arylideneisobenzofuran-1(3H)-one derivatives from phthalic anhydride and quinoline derivatives.
• In the preparation of hyperbranched poly ethoxy siloxanes by condensation reaction with tetra ethoxy silane in presence of an organotitanium catalyst.

分析報告

Assay (GC, area%): ≥ 98.0 % (a/a)
Density (d 20 °C/ 4 °C): 1.080 - 1.082
Identity (IR): passes test

安全信息

• 象形圖: GHS02,GHS05,GHS06
• 訊號詞: Danger
• 危險聲明: H226 - H302 - H314 - H330
• 防範說明: P210 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• 危險分類: Acute Tox. 2 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 3 - Skin Corr. 1B
• 儲存類別代碼: 3 - Flammable liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: 120.2 °F - closed cup
• 閃點（°C）: 49 °C - closed cup