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662056

Sigma-Aldrich

泛素醛

≥95% (HPLC), liquid, ubiquitin hydrolase inhibitor, Calbiochem®

别名:

ubiquitin hydrolase inhibitor

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About This Item

分類程式碼代碼:
12352200
NACRES:
NA.77

product name

泛素醛, Potent and specific inhibitor of multiple ubiquitin hydrolases involved in pathways of intracellular protein modification and turnover.

品質等級

100

化驗

≥95% (HPLC)

形狀

liquid

製造商／商標名

Calbiochem®

儲存條件

OK to freeze

溶解度

DMSO: 50 mg/mL
aqueous buffer: soluble

運輸包裝

ambient

儲存溫度

−20°C

一般說明

多种泛素水解酶（参与细胞内蛋白质修饰和转换途径）的有效和特异性抑制剂。用于稳定内源性或体外合成的泛素-蛋白质偶联物。也可用于提高或降低泛素依赖性降解速率。

生化／生理作用

主要靶标
多种泛素水解酶（参与细胞内蛋白质修饰和转换途径）
产物不与ATP竞争。
可逆：否
显示抑制异肽酶T（目录号419700）和泛素C末端水解酶（目录号662090）的活性
细胞可渗透性：否

包裝

特定浓度批号请参考小瓶的标签。

警告

毒性：标准处理（A）

外觀

在150 mM HCL中。

重構

复溶后，等分并冷冻保存（-20°C）。

其他說明

Melandri, F., et al. 1996.Biochemistry 35, 12893.
Shaeffer, J.R. and Cohen, R.E.1996.Biochemistry 35, 10886.
Pickart, C.M. and Rose, I.A.1986.J. Biol. Chem. 261, 10210.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 1

閃點（°F）

Not applicable

閃點（°C）

Not applicable

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

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Mengmeng Niu et al.
PLoS biology, 19(2), e3001113-e3001113 (2021-02-25)
Transforming growth factor-β (TGF-β) signaling plays a critical role in promoting epithelial-to-mesenchymal transition (EMT), cell migration, invasion, and tumor metastasis. ΔNp63α, the major isoform of p63 protein expressed in epithelial cells, is a key transcriptional regulator of cell adhesion program
Mengmeng Niu et al.
Nature communications, 12(1), 5919-5919 (2021-10-13)
Abnormal activation of epidermal growth factor receptor (EGFR) drives non-small cell lung cancer (NSCLC) development. EGFR mutations-mediated resistance to tyrosine-kinase inhibitors (TKIs) is a major hurdle for NSCLC treatment. Here, we show that F-box protein FBXL2 targets EGFR and EGFR

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