580561

TCEP，中性

A ready-to-use stable, neutral form of the popular disulfide-reducing agent TCEP, Hydrochloride.

• 别名: TCEP，中性
• 经验公式（希尔记法）: C₉H₁₂ClNa₄O₆P
• 分子量: 374.57
• 分類程式碼代碼: 12352128
• NACRES: NA.25

属性

• 品質等級: 100
• 形狀: solid
• 反應適用性: reagent type: reductant
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; desiccated
• 顏色: off-white
• 溶解度: water: soluble
• 運輸包裝: ambient
• 儲存溫度: −20°C

说明

一般說明

一种即用型稳定、中性形式的TCEP盐酸盐（目录号580560），一种二硫化物还原剂。

一种即用型稳定、中性形式的常用二硫化物还原剂TCEP，盐酸盐（目录号580560)0）。用1 ml H₂O复溶每个小瓶，以获得500 mM溶液。

應用

• Förster Resonance Energy Transfer Assay for Investigating the Reactivity of Thioesters in Biochemistry and Native Chemical Ligation.: This study utilizes TCEP in a FRET assay to explore thioester reactivity, providing insights into biochemical reactions and peptide synthesis applications (Gless et al., 2023).


• Two-Dimensional Capillary Zone Electrophoresis-Mass Spectrometry: Intact mAb Charge Variant Separation Followed by Peptide Level Analysis Using In-Capillary Digestion.: TCEP is employed for in-capillary digestion to enhance protein separation and analysis, improving the characterization of monoclonal antibodies (Schlecht et al., 2023).


• Silica Nanoparticle-Loaded Thermoresponsive Block Copolymer Vesicles: A New Post-Polymerization Encapsulation Strategy and Thermally Triggered Release.: TCEP is used in the synthesis of block copolymer vesicles, facilitating the encapsulation and controlled release of nanoparticles for biomedical applications (Czajka et al., 2022).


• Thiol Catalysis of Selenosulfide Bond Cleavage by a Triarylphosphine.: This research demonstrates the use of TCEP in catalyzing selenosulfide bond cleavage, contributing to the understanding of thiol-based reduction mechanisms (Firstova et al., 2022).


• A Novel PNGase Rc for Improved Protein N-Deglycosylation in Bioanalytics and Hydrogen-Deuterium Exchange Coupled With Mass Spectrometry Epitope Mapping Under Challenging Conditions.: TCEP is highlighted for its role in improving protein deglycosylation and mass spectrometry analysis, enhancing bioanalytical techniques (Gramlich et al., 2022).

包裝

用惰性气体包装

警告

毒性：腐蚀性（L）

重構

复溶后，等分，并用惰性气体冲洗并冷冻（-20°C）。贮备溶液在-20°C下可稳定保存至多1个月。

用1 ml水复溶以获得500 mM溶液。

其他說明

Getz, E.B., et al. 1999.Anal.Biochem.273, 73.
Han, J.C. and Han, G.Y.1994.Anal.Biochem.220, 5.
Burns, J.A., et al. 1991.J. Org.Chem.56, 2648.

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法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable