推荐产品
品質等級
化驗
≥95% (HPLC)
形狀
liquid
製造商／商標名
Calbiochem®
儲存條件
OK to freeze
desiccated (hygroscopic)
protect from light
儲存溫度
−70°C
一般說明
Inhibits the tyrosine kinase activity of FGFR1 (IC50 = 10-20 µM in the presence of 1 mM ATP) by interacting with the catalytic domain of FGFR1. Also inhibits aFGF-induced phosphorylation of ERK1 and ERK2 (IC50 = 10-20 µM). In contrast to SU4984, it acts only as a weak inhibitor of tyrosine phosphorylation of the PDGF receptor. Does not inhibit the phosphorylation of insulin receptor and exhibits no inhibitory effect on EGF receptor kinase.
包裝
Packaged under inert gas
警告
Toxicity: Irritant (B)
外觀
A 10 mM (500 µg/169 µl) solution of SU5402 (Cat. No. 572630) in DMSO.
重構
Following initial thaw, aliquot and freeze (-70°C).
其他說明
Mohammadi, M., et al. 1997. Science 276, 955.
法律資訊
Not available for sale in the United States.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
188.6 °F - (refers to pure substance)
閃點（°C）
87 °C - (refers to pure substance)
Lydvina Meister et al.
Development (Cambridge, England), 149(10) (2022-05-17)
The fibroblast growth factor (FGF) signalling pathway plays various roles during vertebrate embryogenesis, from mesoderm formation to brain patterning. This diversity of functions relies on the fact that vertebrates possess the largest FGF gene complement among metazoans. In the cephalochordate
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