435800

Licochalcone-A, Synthetic

An estrogenic flavonoid with anti-tumor and antiparasitic properties.

• 别名: Licochalcone-A, Synthetic, (E)-3-[5-(1,1-Dimethyl-2-propenyl)-4-hydroxy-2-methoxyphenyl]-1-(4-hydroxyphenyl)-2-propen-1-one
• 经验公式（希尔记法）: C₂₁H₂₂O₄
• CAS号: 58749-22-7
• 分子量: 338.40
• MDL號碼: MFCD01417903
• 分類程式碼代碼: 12352200
• NACRES: NA.77

属性

• 品質等級: 100
• 化驗: ≥96% (HPLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: yellow
• 溶解度: DMSO: 10 mg/mL; ethanol: soluble
• 運輸包裝: ambient
• 儲存溫度: −20°C
• InChI: 1S/C21H22O4/c1-5-21(2,3)17-12-15(20(25-4)13-19(17)24)8-11-18(23)14-6-9-16(22)10-7-14/h5-13,22,24H,1H2,2-4H3/b11-8+
• InChI 密鑰: KAZSKMJFUPEHHW-DHZHZOJOSA-N

说明

一般說明

An estrogenic flavanoid with anti-tumor and anti-parasitic properties. Shown to reduce Bcl-2 protein expression and induce apoptosis in several human cancer cell lines. Also induces cell differentiation and enhances the effect of paclitaxel and vinblastine chemotherapy. Reported to interfere with parasite mitochondrial electron transport chain and energy metabolism.

An estrogenic flavonoid with anti-tumor and antiparasitic properties. Shown to reduce Bcl-2 protein expression and induce apoptosis in several human cancer cell lines. Also induces cell differentiation, exhibits anti-tumor activity, and enhances the effect of Paclitaxel (Cat. No. 580555) and Vinblastine (Cat. No. 677175) chemotherapy. Reported to interfere with parasite mitochondrial electron transport chain and energy metabolism.

生化／生理作用

Cell permeable: no

Primary Target
Anti-tumor and antiparasitic properties

Product does not compete with ATP.

Reversible: no

包裝

Packaged under inert gas

警告

Toxicity: Harmful (C)

準備報告

Further dilute 1:10 with aqueous buffer or medium just prior to use.

重構

Following reconstitution aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C.

其他說明

Rafi, M.M., et al. 2000. Anticancer Res. 20, 2653.
Zhai, L., et al. 1999. J. Antimicrob. Chemother. 43, 793.
Haraguchi, H., et al. 1998. Phytochemistry 48, 125.
Park, E.J., et al. 1998. Planta Med. 64, 464.
Chen, M., et al. 1994. Antimicrob. Agents Chemother. 38, 1470.
Chen, M., et al. 1993. Antimicrob. Agents. Chemother. 37, 2550.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H302 + H312 + H332
• 防範說明: P261 - P264 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312
• 危險分類: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable