推荐产品
product name
颗粒酶B抑制剂I, The Granzyme B Inhibitor I controls the biological activity of Granzyme B. This small molecule/inhibitor is primarily used for Cancer applications.
品質等級
化驗
≥95% (HPLC)
形狀
solid
製造商／商標名
Calbiochem®
儲存條件
OK to freeze
desiccated
顏色
off-white
溶解度
DMSO: 5 mg/mL
運輸包裝
ambient
儲存溫度
−20°C
一般說明
人和鼠丝氨酸蛋白酶颗粒酶B的弱抑制剂。还通过片段化蛋白2（一种与颗粒酶B同源的大鼠淋巴细胞颗粒蛋白酶）抑制淋巴细胞中与凋亡相关的DNA片段化（ID50=300 nM）。
人和鼠颗粒酶B的弱抑制剂。还通过片段化蛋白2（一种与颗粒酶B同源的大鼠淋巴细胞颗粒蛋白酶）抑制淋巴细胞中与凋亡相关的DNA片段化（ID50=300 nM）。
生化／生理作用
主要靶标
颗粒酶B
颗粒酶B
产物不与ATP竞争。
可逆：否
细胞可渗透性：是
靶标IC50：300 nM，针对片段化蛋白2引起的淋巴细胞凋亡相关DNA片段化
警告
毒性：标准处理（A）
序列
Z-Ala-Ala-Asp-CH₂Cl
重構
复溶后，等分并冷冻保存（-20°C）。储备溶液在-20°C下可稳定保存至多3个月。
其他說明
Gong, B., et al. 1999.Cell Growth Different.10, 491.
Shi, L., et al. 1992.J. Exp.Med. 176, 1521.
Odake, S., et al. 1991.Biochemistry30, 2217.
Shi, L., et al. 1992.J. Exp.Med. 176, 1521.
Odake, S., et al. 1991.Biochemistry30, 2217.
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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Hippocampal neuronal apoptosis is a devastating consequence of cardiac arrest (CA) and subsequent cardiopulmonary resuscitation (CPR). In this study, we assessed the contribution of cytotoxic T lymphocyte (CTL)-derived toxic mediator granzyme B (Gra-b) to the hippocampal neuronal apoptosis following CA/CPR
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Penetration of immune cells into tumor cells was believed to be immune-suppressive via cell-in-cell (CIC) mediated death of the internalized immune cells. We unexpectedly found that CIC formation largely led to the death of the host tumor cells, but not
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