推荐产品
品質等級
化驗
≥95% (HPLC)
形狀
solid
製造商／商標名
Calbiochem®
儲存條件
OK to freeze
desiccated (hygroscopic)
顏色
orange
溶解度
DMSO: 3 mg/mL
aqueous base: soluble
運輸包裝
ambient
儲存溫度
10-30°C
InChI
1S/C14H10N4O5.Na/c19-13-8-17(14(20)16-13)15-7-11-5-6-12(23-11)9-1-3-10(4-2-9)18(21)22;/h1-7H,8H2,(H,16,19,20);/q;+1/p-1/b15-7+;
InChI 密鑰
KSRLIXGNPXAZHD-HAZZGOGXSA-M
一般說明
从肌浆网释放的细胞内钙的细胞渗透性阻滞剂，通过与ryanodine受体结合起作用。抑制突触传递的长期抑郁和去势化。对大脑缺血有神经保护作用。
骨骼肌肉松弛药。通过与ryanodine受体结合，在激发-收缩偶联过程中阻止细胞内钙从肌浆网释放。阻止长期抑郁和去势化。
生化／生理作用
主要靶标
Ryanodine受体
Ryanodine受体
产物不与ATP竞争。
可逆：否
细胞可渗透性：是
警告
毒性：有害（C）
重構
复溶后，等分并冷冻保存（-20°C）。储备液在-20°C条件下可稳定保存3个月。
其他說明
Wei, H., and Perry, D.C. 1996.J. Neurochem.67, 2390.
O’Mara, S.M., et al. 1995.Neuroscience68, 621.
Parness, J., and Palnitkar, S.S.1995.J. Biol. Chem.270, 18465.
Zhang, H., et al. 1995.Am. J. Physiol.269, H1874.
Hotchkiss, R.S., and Karl, I.E.1994.Proc.Natl.Acad.Sci. USA91, 3039.
Song, S.K., et al. 1994.Proc.Natl.Acad.Sci. USA91, 3039.
O’Mara, S.M., et al. 1995.Neuroscience68, 621.
Parness, J., and Palnitkar, S.S.1995.J. Biol. Chem.270, 18465.
Zhang, H., et al. 1995.Am. J. Physiol.269, H1874.
Hotchkiss, R.S., and Karl, I.E.1994.Proc.Natl.Acad.Sci. USA91, 3039.
Song, S.K., et al. 1994.Proc.Natl.Acad.Sci. USA91, 3039.
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Christopher B Sylvester et al.
Frontiers in cardiovascular medicine, 10, 1112965-1112965 (2023-04-18)
Calcific aortic valve disease (CAVD), a fibrocalcific thickening of the aortic valve leaflets causing obstruction of the left ventricular outflow tract, affects nearly 10 million people worldwide. For those who reach end-stage CAVD, the only treatment is highly invasive valve
Joseph E Pick et al.
The EMBO journal, 36(2), 232-244 (2016-11-20)
mGluR long-term depression (mGluR-LTD) is a form of synaptic plasticity induced at excitatory synapses by metabotropic glutamate receptors (mGluRs). mGluR-LTD reduces synaptic strength and is relevant to learning and memory, autism, and sensitization to cocaine; however, the mechanism is not
Sarayu Ramakrishna et al.
Life science alliance, 7(8) (2024-05-16)
Calcium signaling is integral for neuronal activity and synaptic plasticity. We demonstrate that the calcium response generated by different sources modulates neuronal activity-mediated protein synthesis, another process essential for synaptic plasticity. Stimulation of NMDARs generates a protein synthesis response involving
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门