07-2192

Anti-phospho-TBK1 (Ser172) Antibody

from rabbit, purified by affinity chromatography

• 别名: Serine/threonine-protein kinase TBK1, NF-kappa-B-activating kinase, T2K, TANK-binding kinase 1
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702

属性

• 生物源: rabbit
• 品質等級: 100
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 純化經由: affinity chromatography
• 物種活性: mouse, human
• 物種活性（以同源性預測）: rat (based on 100% sequence homology)
• 技術: western blot: suitable
• NCBI登錄號: NP_037386
• UniProt登錄號: Q9UHD2
• 運輸包裝: wet ice
• 目標翻譯後修改: phosphorylation (pSer172)
• 基因資訊: human ... TBK1(29110)

说明

一般說明

TBK, also known as IκB kinase (IKK)-related kinase NAK, belong to the serine/threonine IKK kinase family and is thought to play a role in NF-kappa-B (NF-κB) activation. The NF-κB complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NF-κB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NF-κB activation in response to certain growth factors. For example, the protein can form a complex with the IKB protein TANK and TRAF2 and release the NF-κB inhibition caused by TANK.

特異性

This antibody recognizes TBK1 phosphorylated at Ser172.

免疫原

KLH-conjugated linear peptide corresponding to human TBK1 phosphorylated at Ser172.

應用

This phospho-TBK1 antibody is validated for use in WB for the detection of the phospho-TBK1 protein.

品質

Evaluated by Western Blot in EGF treated and untreated HEK293 cell lysates.

Western Blot Analysis: 1:1,000 dilution of this antibody detected TBK1 on 10 µg of EGF treated and untreated HEK293 cell lysates.

標靶描述

~90 kDa observed

分析報告

Control
EGF treated and untreated HEK293 cell lysates

安全信息

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable