推荐产品
生物源
mouse
品質等級
抗體表格
affinity purified immunoglobulin
抗體產品種類
primary antibodies
無性繁殖
N4.4, monoclonal
物種活性
mouse, human
製造商／商標名
Upstate®
技術
immunoprecipitation (IP): suitable
western blot: suitable
同型
IgG1
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
目標翻譯後修改
unmodified
基因資訊
human ... KMT2A(4297)
一般說明
The acute lymphoblastic leukaemia (ALL)-1 (also known as MLL, HRX, HTRX, and TRX1) gene on human chromosome 11q23 is the site of many locally clustered chromosomal alterations associated with several types of acute leukaemias, including deletions, partial duplications and translocations. Structurally variant proteins derived from the altered gene presumably cause the malignant transformation of early haemopoietic progenitor cells.
特異性
Recognizes N-terminal proteolytic fragment of MLL (MLLN).
免疫原
MBP fusion protein corresponding to residues 161-356 of human mixed lineage leukemia, MLL
應用
Detect MLL/HRX with Anti-MLL/HRX Antibody, N-term., clone N4.4 (Mouse Monoclonal Antibody), that has been shown to work in IP & WB.
品質
routinely evaluated by immunoblot on nuclear extract from K562 cells
標靶描述
300 kDa
外觀
Format: Purified
Immunoaffinity Purified immunoglobulin in 0.014M phosphate buffer, pH 7.6, 0.175M NaCl, 0.07% sodium azide, and 30% glycerol.
其他說明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
法律資訊
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
Chi Wai So et al.
Molecular and cellular biology, 22(18), 6542-6552 (2002-08-23)
MLL-AFX is a fusion gene created by t(X;11) chromosomal translocations in a subset of acute leukemias of either myeloid or lymphoid derivation. It codes for a chimeric protein consisting of MLL fused to AFX, a forkhead transcription factor that normally
Inducible MLL-AF9 Expression Drives an AML Program during Human Pluripotent Stem Cell-Derived Hematopoietic Differentiation.
Heuts, et al.
Cells, 12 (2023)
J Paggetti et al.
Oncogene, 29(36), 5019-5031 (2010-06-29)
MOZ and MLL, encoding a histone acetyltransferase (HAT) and a histone methyltransferase, respectively, are targets for recurrent chromosomal translocations found in acute myeloblastic or lymphoblastic leukemia. In MOZ (MOnocytic leukemia Zinc-finger protein)/CBP- or mixed lineage leukemia (MLL)-rearranged leukemias, abnormal levels
Anmaar M Abdul-Nabi et al.
PloS one, 5(8), e12464-e12464 (2010-09-02)
Different fusion oncogenes in acute myeloid leukemia (AML) have distinct clinical and laboratory features suggesting different modes of malignant transformation. Here we compare the in vitro effects of representatives of 4 major groups of AML fusion oncogenes on primary human
Stefanie Meier et al.
Cell death & disease, 12(8), 785-785 (2021-08-13)
Pediatric gliomas comprise a broad range of brain tumors derived from glial cells. While high-grade gliomas are often resistant to therapy and associated with a poor outcome, children with low-grade gliomas face a better prognosis. However, the treatment of low-grade
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