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Merck

Androstenediol analogs as ER-beta-selective SERMs.

Bioorganic & medicinal chemistry letters (2005-11-29)
Timothy A Blizzard, Candido Gude, Jerry D Morgan, Wanda Chan, Elizabeth T Birzin, Marina Mojena, Consuelo Tudela, Fang Chen, Kristin Knecht, Qin Su, Bryan Kraker, Ralph T Mosley, Mark A Holmes, Nandini Sharma, Paula M D Fitzgerald, Susan P Rohrer, Milton L Hammond
ABSTRACT

A series of 19-substituted androstenediol derivatives was prepared. Some of the novel analogs were surprisingly potent and selective ligands for ER-beta.

MATERIALS
Product Number
Brand
Product Description

Supelco
Testosterone, VETRANAL®, analytical standard
Sigma-Aldrich
β-Estradiol, powder, γ-irradiated, suitable for cell culture
Sigma-Aldrich
β-Estradiol, analytical standard
Sigma-Aldrich
β-Estradiol, BioReagent, powder, suitable for cell culture
Supelco
Testosterone solution, 1.0 mg/mL in 1,2-dimethoxyethane, drug standard
Sigma-Aldrich
β-Estradiol, ≥98%
Sigma-Aldrich
Estradiol, meets USP testing specifications