F2379
Fetuin from fetal bovine serum
lyophilized powder, suitable for cell culture
Synonym(s):
Fetuin from fetal calf serum
Sign Into View Organizational & Contract Pricing
All Photos(5)
About This Item
Recommended Products
biological source
bovine serum (fetal)
form
lyophilized powder
technique(s)
cell culture | mammalian: suitable
impurities
≤0.3% free N-acetylneuraminic acid
solubility
H2O: 1 mg/mL, colorless to faint yellow or tan
UniProt accession no.
storage temp.
2-8°C
Gene Information
bovine ... FETUB(504615)
Looking for similar products? Visit Product Comparison Guide
General description
Fetuin from fetal bovine serum is a 64 kDa plasma glycoprotein. It is produced by the liver and adipose tissue.
Application
Fetuin from fetal bovine serum has been used:
- to synthesize primary and secondary calciprotein particles (CPP)
- to study the binding of Xerocomus chrysenteron lectin (XCL) to the T antigen expressed by membrane proteins
- as a supplement in Ham′s F10 media for myoblast culture.
Fetuin is a protein with the ability to bind to the insulin receptor and inhibit insulin action. Fetuin has been used in studies of type 2 diabetes mellitus (T2DM). In patients with T2DM, fetuin has been shown to be significantly lower when compared to control patients. Fetuin has also been used in studies to demonstrate its protective role in the development of arterial calcification.
Biochem/physiol Actions
Fetuin, an inhibitor of insulin receptor tyrosine kinase, modulates bone remodeling and calcium metabolism. It is involved in keratinocytes migration and breast tumor cell proliferative signaling. Fetuin also regulates vascular calcification, insulin resistance and protease activity It acts as a biomarker for neurodegenerative diseases. Fetuin has anti-inflammatory property.
Preparation Note
Prepared by ammonium sulfate fractionation of fetal bovine serum by the method of Pederson, K.O., J. Phys. and Colloid Chem., 51, 164 (1947).
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Customers Also Viewed
A protein nanocontainer targeting epithelial cancers: rational engineering, biochemical characterization, drug loading and cell delivery
Ladurantie C, et al.
Nanoscale, 11(7), 3248-3260 (2019)
mTORC1 regulates mitochondrial integrated stress response and mitochondrial myopathy progression
Khan NA, et al.
Cell Metabolism, 26(2), 419-428 (2017)
Pietro Allevi et al.
Journal of chromatography. A, 1212(1-2), 98-105 (2008-10-28)
The present report describes a method for the quantification of N-acetyl- and N-glycolylneuraminic acids without any derivatization, using their (13)C(3)-isotopologues as internal standards and a C(18) reversed-phase column modified by decylboronic acid which allows for the first time a complete
Kevan L Hartshorn et al.
American journal of physiology. Lung cellular and molecular physiology, 298(1), L79-L88 (2009-10-20)
Collectins are collagenous lectins present in blood, respiratory lining fluid, and other mucosal secretions that play important roles in innate defense against infection. The collectin, surfactant protein D (SP-D), limits infection by viruses and bacteria in the respiratory tract, eye
Cellular clearance and biological activity of calciprotein particles depend on their maturation state and crystallinity
Koeppert S, et al.
Frontiers in Immunology, 9, 1991-1991 (2018)
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service