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Key Documents

422R-1

Sigma-Aldrich

PHOX2B (EP312) Rabbit Monoclonal Primary Antibody

Synonym(s):

Paired-like Homeobox 2B

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About This Item

UNSPSC Code:
12352203

biological source

rabbit

Quality Level

100
500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

EP312, monoclonal

description

For In Vitro Diagnostic Use in Select Regions

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (422R-14)
vial of 0.1 mL concentrate Research Use Only (422R-14-RUO)
vial of 0.5 mL concentrate (422R-15)
vial of 1.0 mL concentrate (422R-16)
vial of 1.0 mL concentrate Research Use Only (422R-16-RUO)
vial of 1.0 mL pre-dilute Research Use Only (422R-17-RUO)
vial of 1.0 mL pre-dilute ready-to-use (422R-17)
vial of 7.0 mL pre-dilute ready-to-use (422R-18)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (422R-18-RUO)

manufacturer/tradename

Cell Marque™

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100 (concentrated)

isotype

IgG

control

neuroblastoma

shipped in

wet ice

storage temp.

2-8°C

visualization

nuclear

Gene Information

human ... PHOX2B(8929)

General description

Paired-like homeobox 2B (PHOX2B) is a transcription factor located on chromosome 4p13 which is crucial to the formation of autonomic ganglia in the autonomic nervous system (ANS). PHOX2B gene is strictly expressed in neural crest derivatives committed to the noradrenergic phenotype. The PHOX2B gene encodes a paired-like homeo-domain transcription factor with an extra-axial expression pattern restricted to the ANS. Neuroblasts of peripheral neuroblastic tumors are derived from the sympathoadrenal lineage, a division of the ANS. PHOX2B has been observed in peripheral neuroblastic tumors, neuroblastomas, paragangliomas, ganglioneuroblastomas, ganglioneuromas and pheochromocytomas. PHOX2B has been reported to be negative in other small round blue cell tumors.

Quality


IVD
IVD
IVD
RUO

Linkage

PHOX2B Positive Control Slides, Product No. 422S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

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Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Daisuke Nonaka et al.
The American journal of surgical pathology, 37(8), 1236-1241 (2013-05-30)
Autonomic neurons and chromaffin cells, which constitute the autonomic nervous system, are derived from a common progenitor from the neural crest, and its development is controlled by a network of transcription factors, including the master regulator, Phox2b, and its downstream
A Pattyn et al.
Nature, 399(6734), 366-370 (1999-06-09)
The sympathetic, parasympathetic and enteric ganglia are the main components of the peripheral autonomic nervous system, and are all derived from the neural crest. The factors needed for these structures to develop include the transcription factor Mash1, the glial-derived neurotrophic
Franck Bielle et al.
The American journal of surgical pathology, 36(8), 1141-1149 (2012-07-14)
Peripheral neuroblastic tumors are the most commonly occurring extracranial tumors in children. Although a reliable diagnosis is achievable in the majority of cases, diagnosis of a minority of peripheral neuroblastic tumor cases (especially undifferentiated neuroblastoma) poses a challenge compared with
Franck Bourdeaut et al.
Cancer letters, 228(1-2), 51-58 (2005-06-14)
Hereditary predisposition to neuroblastoma accounts for less than 5% of neuroblastomas and is probably heterogeneous. Recently, a predisposition gene has been mapped to 16p12-p13, but has not yet been identified. Occurrence of neuroblastoma in association with congenital central hypoventilation and
L Longo et al.
International journal of oncology, 33(5), 985-991 (2008-10-25)
The detection of PHOX2B mutations in a small proportion of patients affected with either familial or sporadic neuroblastoma (NB), has arisen interest on the possible pathogenic role of this gene in the disease determination. In this light, we have carried

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