Combination therapy: histone deacetylase inhibitors and platinum-based chemotherapeutics for cancer.

Combination therapy: histone deacetylase inhibitors and platinum-based chemotherapeutics for cancer.

Cancer letters (2012-10-04)

Himashinie V K Diyabalanage, Michael L Granda, Jacob M Hooker

ABSTRACT

One of the most promising strategies to increase the efficacy of standard chemotherapy drugs is by combining them with low doses of histone deacetylases inhibitors (HDACis). Regarded as chemosensitizers, the addition of well-tolerated doses of HDACis to platinum-based chemotherapeutics has been proven in vitro and in vivo in recent studies for many cancer types and stages. In this review, we discuss the most commonly used combinations of histone deacetylase inhibitors and platinum based drugs in the context of their possible mechanisms, efficiency, efficacy, and related drawbacks in preclinical and clinical studies.

MATERIALS

Product Number

Brand

Product Description

444685

Sigma-Aldrich

Platinum, wire, diam. 2.0 mm, 99.9% trace metals basis

349321

Sigma-Aldrich

Platinum, foil, thickness 0.25 mm, 99.99% trace metals basis

349380

Sigma-Aldrich

Platinum, foil, thickness 0.1 mm, 99.9% trace metals basis

349348

Sigma-Aldrich

Platinum, foil, thickness 0.127 mm, 99.99% trace metals basis

205915

Sigma-Aldrich

Platinum black, black, powder, ≤20 μm, ≥99.95% trace metals basis

357375

Sigma-Aldrich

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520780

Sigma-Aldrich

Platinum black, fuel cell grade, ≥99.9% trace metals basis

298093

Sigma-Aldrich

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267821

Sigma-Aldrich

Platinum, wire, diam. 0.127 mm, 99.9% trace metals basis

520799

Sigma-Aldrich

Platinum black, low bulk density, ≥99.9% trace metals basis

267244

Sigma-Aldrich

Platinum, foil, thickness 0.025 mm, 99.9% trace metals basis

327484

Sigma-Aldrich

Platinum, shot, ≤3 mm, ≥99.9% trace metals basis

349402

Sigma-Aldrich

Platinum, wire, diam. 0.25 mm, 99.9% trace metals basis

GF49812510

Platinum, tube, 100mm, outside diameter 3.0mm, inside diameter 2.8mm, wall thickness 0.1mm, as drawn, 99.95%

GF91208909

Platinum, microfoil, disks, 25mm, thinness 0.1μm, specific density 120μg/cm², permanent mylar 3.5μm support, 99.99%

GF72819715

Platinum, foil, 25x25mm, thickness 0.25mm, as rolled, 99.99+%

GF78532319

Platinum, wire reel, 0.05m, diameter 0.175mm, as drawn, 99.95%

GF71546429

Platinum, rod, 25mm, diameter 1.0mm, 99.95%

GF87686173

Platinum, foil, 30x30mm, thickness 0.2mm, as rolled, 99.95%

GF78892981

Platinum, wire reel, 0.05m, diameter 0.8mm, annealed, may be used as one component of a thermocouple, 99.99%

GF21472141

Platinum, rod, 10mm, diameter 4.0mm, 99.95%

GF17993368

Platinum, foil, 10mm disks, thickness 0.125mm, as rolled, 99.95%

GF51572572

Platinum, insulated wire, 5m, conductor diameter 0.05mm, insulation thickness 0.009mm, PTFE (polytetrafluoroethylene) insulation, 99.99%

GF09436619

Platinum, tube, 200mm, outside diameter 0.95mm, inside diameter 0.60mm, wall thickness 0.175mm, as drawn, 99.95%

GF43288487

Platinum, wire reel, 0.05m, diameter 1.0mm, annealed, may be used as one component of a thermocouple, 99.99%

GF35428406

Platinum, foil, 15x15mm, thickness 0.2mm, as rolled, 99.95%

GF55231118

Platinum, wire reel, 0.05m, diameter 1.0mm, as drawn, 99.99+%

GF37488268

Platinum, foil, 8mm disks, thickness 0.004mm, as rolled, 99.95%

GF63387108

Platinum, foil, 10mm disks, thickness 0.125mm, as rolled, 99.99+%

GF93413493

Platinum, wire reel, 0.1m, diameter 0.15mm, annealed, may be used as one component of a thermocouple, 99.99%