Enhancement effect of cytotoxicity response of silver nanoparticles combined with thermotherapy on C6 rat glioma cells.

Enhancement effect of cytotoxicity response of silver nanoparticles combined with thermotherapy on C6 rat glioma cells.

Journal of nanoscience and nanotechnology (2013-07-19)

Rui Wang, Chunmei Chen, Weizhong Yang, Songsheng Shi, Chunhua Wang, Jing Chen

ABSTRACT

The present studies reveal that silver nanoparticles (AgNPs) can induce apoptosis and enhance radio-sensitivity on cancer cells. In this paper, we mainly investigated the effect of AgNPs on rat glioma C6 cells upon the combination treatment of hyperthermia treatment (HTT). AgNPs were synthesized by a polyol process and the mean size was 15 nm. The particles showed dose-dependent cytotoxicity on C6 cells from the experimental data. Besides, we found that heating cells could enhance the contents of cell uptake of AgNPs. From the survival curves, AgNPs showed the ability to enhance thermo-sensitivity on C6 cells. Our results revealed that AgNPs could have a potential application in enhancing effect on HTT induced killing of glioma cells.

MATERIALS

Product Number

Brand

Product Description

735825

Sigma-Aldrich

Silver, conductive paste

739421

Sigma-Aldrich

Silver nanowires, diam. × L 50 nm × 6 μm, 0.5% (isopropyl alcohol suspension)

484059

Sigma-Aldrich

Silver, nanopowder, <150 nm particle size, 99% trace metals basis

369438

Sigma-Aldrich

Silver, foil, thickness 1.0 mm, 99.99% trace metals basis

326976

Sigma-Aldrich

Silver, foil, thickness 2.0 mm, 99.9% trace metals basis

265586

Sigma-Aldrich

Silver, wire, diam. 0.5 mm, ≥99.99% trace metals basis

265594

Sigma-Aldrich

Silver, wire, diam. 1.0 mm, ≥99.99% trace metals basis

265608

Sigma-Aldrich

Silver, wire, diam. 1.0 mm, 99.9% trace metals basis

327050

Sigma-Aldrich

Silver, shot, 1-3 mm, ≥99.99% trace metals basis

265500

Sigma-Aldrich

Silver, powder, <250 μm, 99.99% trace metals basis

295744

Sigma-Aldrich

Silver, wool, diam. 0.05 mm, ≥99.9% trace metals basis

265527

Sigma-Aldrich

Silver, foil, thickness 0.1 mm, 99.9% trace metals basis

85131

Sigma-Aldrich

Silver, colloidal, 65-75% Ag basis

348783

Sigma-Aldrich

Silver, wire, diam. 0.1 mm, 99.9% trace metals basis

265551

Sigma-Aldrich

Silver, wire, diam. 0.127 mm, 99.99% trace metals basis

739448

Sigma-Aldrich

Silver nanowires, diam. × L 100 nm × 6 μm, 0.5% (isopropyl alcohol suspension)

576832

Sigma-Aldrich

Silver, nanopowder, <100 nm particle size, contains PVP as dispersant, 99.5% trace metals basis

327018

Sigma-Aldrich

Silver, wire, diam. 2.0 mm, 99.9% trace metals basis

265578

Sigma-Aldrich

Silver, wire, diam. 0.25 mm, 99.9% trace metals basis

326984

Sigma-Aldrich

Silver, foil, thickness 0.25 mm, 99.9% trace metals basis

265519

Sigma-Aldrich

Silver, foil, thickness 0.025 mm, 99.9% trace metals basis

327085

Sigma-Aldrich

Silver, powder, 2-3.5 μm, ≥99.9% trace metals basis

327034

Sigma-Aldrich

Silver, wire, diam. 0.25 mm, ≥99.99% trace metals basis

327093

Sigma-Aldrich

Silver, powder, 5-8 μm, ≥99.9% trace metals basis

267430

Sigma-Aldrich

Silver, wire, diam. 2.0 mm, ≥99.99% trace metals basis

303372

Sigma-Aldrich

Silver, granular, >250 μm, 99.99% trace metals basis

373249

Sigma-Aldrich

Silver, evaporation slug, diam. × L 0.6 cm × 1.2 cm, 99.99% trace metals basis

348759

Sigma-Aldrich

Silver, wire, diam. 1.5 mm, ≥99.99% trace metals basis

327026

Sigma-Aldrich

Silver, wire, diam. 0.5 mm, 99.9% trace metals basis

327077

Sigma-Aldrich

Silver, flakes, 10 μm, ≥99.9% trace metals basis