M1821
Anti-Monoamine Oxidase B antibody produced in rabbit
~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-Adrenalin oxidase, Anti-MAO, brain, Anti-MAO, platelet, Anti-Tyramine oxidase
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
Pricing and availability is not currently available.
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biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~58 kDa
species reactivity
mouse, rat, human
concentration
~1.5 mg/mL
technique(s)
western blot: 0.5-1.0 μg/mL using rat liver mitochondrial fraction
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... ASCC3(10973) , MAOB(4129)
rat ... Maob(25750)
General description
Monoamine Oxidase B (MAO-B) is a mitochondrial flavo enzyme. It is mainly found in the brain in dopaminergic, serotonergic, and histaminergic neurons and astrocytes.
Monoamine Oxidase B is encoded by the gene mapped to human chromosome Xp11.3.
Specificity
Anti-Monoamine Oxidase B specifically recognizes human, mouse, and rat MAO-B.
Application
Anti-Monoamine Oxidase B antibody has been used in western blotting.[1]
Anti-Monoamine Oxidase B antibody produced in rabbit has also been used in coimmunoprecipitation (co-IP) and immunohistochemistry.[2]
Biochem/physiol Actions
Monoamine oxidase B (MAO-B) is considered the predominant isoform responsible for dopamine metabolism in the human central nervous system (CNS). MAO-B activity correlates with personality traits. Alterations in MAO-B activity may underlie dopamine pathobiology in major depression. Selective MAO-B inhibitors elevate synaptosomal dopamine concentrations, and have recently shown clinical efficacy in the treatment of early Parkinson′s disease.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Storage and Stability
For continuous use, store at 2–8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Description
Pricing
Storage Class Code
10 - Combustible liquids
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Ryan E O'Leary et al.
European journal of medical genetics, 55(5), 349-353 (2012-03-01)
Monoamine oxidase A and B (MAOA and MAOB) play key roles in deaminating neurotransmitters and various other biogenic amines. Patients deficient in one or both enzymes have distinct metabolic and neurologic profiles. MAOB deficient patients exhibit normal clinical characteristics and
Structure of human monoamine oxidase B, a drug target for the treatment of neurological disorders
Binda C, et al.
Nature Structural and Molecular Biology, 9(1), 22-22 (2002)
Rasagiline [N-propargyl-1R (+)-aminoindan], a selective and potent inhibitor of mitochondrial monoamine oxidase B
Youdim M, et al.
British Journal of Pharmacology, 132(2), 500-506 (2001)
Dorit Trudler et al.
Journal of neurochemistry, 129(3), 434-447 (2013-12-21)
DJ-1 is an oxidative stress sensor that localizes to the mitochondria when the cell is exposed to oxidative stress. DJ-1 mutations that result in gene deficiency are linked to increased risk of Parkinson's disease (PD). Activation of microglial stress conditions
Immunocytochemical demonstration of monoamine oxidase B in brain astrocytes and serotonergic neurons
Levitt P, et al.
Proceedings of the National Academy of Sciences of the USA, 79(20), 6385-6389 (1982)
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